ArticleNeuropsychologia2014
A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults.
Article in Neuropsychologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Meta-analysis of cognitive ability differences by apolipoprotein e genotype in young humans.Neuroscience and biobehavioral reviews · 2018Pooled it
- PEARL-Neuro Database: EEG, fMRI, health and lifestyle data of middle-aged people at risk of dementia.Scientific data · 2024Article
- A review of brain imaging biomarker genomics in Alzheimer's disease: implementation and perspectives.Translational neurodegeneration · 2022Review
- Plasma Sphingomyelins in Late-Onset Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- APOE in the normal brain.Neurobiology of disease · 2020Review
- Clusterin in Alzheimer's Disease: Mechanisms, Genetics, and Lessons From Other Pathologies.Frontiers in neuroscience · 2019Review
- EFAD transgenic mice as a humanJournal of lipid research · 2017Review
- The role of APOE on lipid homeostasis and inflammation in normal brains.Journal of lipid research · 2017Review
- Identification and modification of amyloid-independent phenotypes of APOE4 mice.Experimental neurology · 2016Article
- The Biomarkers for Identifying Preclinical Alzheimer's Disease via Structural and Functional Magnetic Resonance Imaging.Frontiers in aging neuroscience · 2016Article
- Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function.Current Alzheimer research · 2016Review
- Neuroimaging genetic risk for Alzheimer's disease in preclinical individuals: From candidate genes to polygenic approaches.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- APOE-modulated Aβ-induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective.Journal of neurochemistry · 2015Review
- A gene-brain-cognition pathway for the effect of an Alzheimer׳s risk gene on working memory in young adults.Neuropsychologia · 2014Article
- Combined effects of Alzheimer risk variants in the CLU and ApoE genes on ventricular expansion patterns in the elderly.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults.Frontiers in human neuroscience · 2014Article
- No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching.Brain and neuroscience advancesArticle
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
A recent history of failed clinical trials suggests that waiting until even the early stages of onset of Alzheimer's disease may be too late for effective treatment, pointing to the importance of early intervention in young people. Early intervention will require markers of Alzheimer's risk that track with genotype but are capable of responding to treatment. Here, we sought to identify a functional MRI signature of combined Alzheimer's risk imparted by two genetic risk factors. We used a task of executive attention during fMRI in participants genotyped for two Alzheimer's risk alleles: APOE-ε4 and CLU-C. Executive attention is a sensitive indicator of the progression of Alzheimer's even in the early stages of mild cognitive impairment, but has not yet been investigated as a marker of Alzheimer's risk in young adults. Functional MRI revealed that APOE-ε4 and CLU-C had an additive effect on brain activity such that increased combined genetic risk was associated with decreased brain activity during executive attention, including in the medial temporal lobe, a brain area affected early in Alzheimer's pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.