Evidence map›Paper›PMID 24388326›Full record

ArticleThe Journal of pediatrics2014

Gestational diabetes mellitus, maternal obesity, and adiposity in offspring.

Kathleen A Page, Ana Romero, Thomas A Buchanan, Anny H Xiang

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04302168 (Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus), which is not on this map. Cited by 47 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 9 pooled it
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04302168 nacompletednot on this mapstarted 2020, after this paper: background citation

Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus

TypeinterventionalSponsorMaimonides Medical CenterRan2020 to 2024Enrolled46ConditionsGestational DiabetesArmsCholine supplement, Placebo
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 9 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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  13. An Observational Study of Maternal Hypoglycemia in Pregnancy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Article
  14. Structural and Functional Brain Changes in Children and Adolescents With Obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kathleen A PageDepartment of Medicine, Keck School of Medicine, the University of Southern California, Los Angeles, CA. Electronic address: kpage@usc.edu.
Ana RomeroDepartment of Medicine, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Thomas A BuchananDepartment of Medicine, Keck School of Medicine, the University of Southern California, Los Angeles, CA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
University of Southern California · USKaiser Permanente · US

Funding

LOS ANGELES BASIN CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR031986 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2010 to 2011
$21.1M
Los Angeles Basin Clinical and Translational Science InstituteKL2RR031991 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2010 to 2011
$1.6M
Maternal gestational diabetes in Hispanic youth: obesity and insulin resistanceK23DK092702 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PAGE, KATHLEEN ALANNA · 2011 to 2015
$775k
NCRR NIH HHS KL2 RR031991NCRR NIH HHS UL1 RR031986NIDDK NIH HHS K23 DK092702
6 · The paper itself

Abstract

objectiveTo determine the effects of maternal gestational diabetes mellitus (GDM) on offspring adiposity in a well-characterized cohort of Mexican American mother-child pairs. STUDY

designThis study included 62 Mexican American mothers and their index offspring. Maternal GDM and normal glucose status during index pregnancy were documented, and mothers were previously matched by age, body mass index (BMI), and parity. Mother-child pairs were recruited when offspring were between the ages of 5 and 16 years. A medical history was collected, and anthropometrics were measured. Main outcome measures were offspring BMI, BMI z-scores, BMI percentiles, and hip and waist circumferences.

resultsGDM-exposed offspring (n = 37) had greater measures of BMI (all P ≤ .02) and greater waist and hip circumferences (both P = .002) compared with 25 offspring of non-GDM mothers. Adjustment for offspring age, sex, Tanner stage, birth weight, months of breastfeeding, maternal prepregnancy BMI, and pregnancy weight gain attenuated the differences, but BMI z-score and BMI percentile remained significantly greater in the GDM-exposed group (P < .05).

conclusionIntrauterine exposure to GDM is associated with greater adiposity in Mexican American children, and this relationship is not mediated by maternal obesity. In contrast to previous reports, this study included only Mexican Americans; thus, ethnic variations may influence the contributions of maternal GDM and maternal obesity to offspring adiposity.

Indexed as

AdiposityBody Mass IndexDiabetes, GestationalAdolescentAdultChildChild, PreschoolFemaleHumansMaleMexican AmericansObesityPregnancy

Identifiers

PMID24388326
PMCPMC3962700
OpenAlexW1991529140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.