ArticleThe Journal of pediatrics2014
Wheezing symptoms and parental asthma are associated with a physician diagnosis of asthma in children with sickle cell anemia.
Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Incremental eligibility criteria for the BMT CTN 1507 haploidentical trial for children with sickle cell disease.Blood advances · 2024Trial
- Inhaled steroids reduce pain and sVCAM levels in individuals with sickle cell disease: A triple-blind, randomized trial.American journal of hematology · 2017Trial
- Article
- Patients with sickle cell disease and asthma have a higher risk for acute chest syndrome: A systematic review and meta-analysis of observational studies.Experimental and therapeutic medicine · 2026Article
- Asthma Is an Independent Risk Factor for Acute Chest Syndrome in Children with Sickle Cell Disease in French Guiana.Children (Basel, Switzerland) · 2024Article
- Respiratory management of acute chest syndrome in children with sickle cell disease.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Exploring the Interplay between Asthma and Hemoglobinopathies: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Lower Arginine Bioavailability, Increased FeNO Levels, and Airway Resistance on Impulse Oscillometry Are Characteristics of Asthma in Children and Young Adults with Sickle Cell Disease.Medicina (Kaunas, Lithuania) · 2024Article
- Hidden Comorbidities in Asthma: A Perspective for a Personalized Approach.Journal of clinical medicine · 2023Review
- The Cardiopulmonary Complications of Sickle Cell Disease.Hematology/oncology clinics of North America · 2022Review
- Management of chronic respiratory complications in children and adolescents with sickle cell disease.European respiratory review : an official journal of the European Respiratory Society · 2020Review
- Haptoglobin genotype predicts severe acute vaso-occlusive pain episodes in children with sickle cell anemia.American journal of hematology · 2020Article
- The role of hydroxyurea in decreasing the occurrence of vasso-occulusive crisis in pediatric patients with sickle cell disease at King Saud Medical City in Riyadh, Saudi Arabia.Saudi medical journal · 2020Article
- Identifying Clinical and Research Priorities in Sickle Cell Lung Disease. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2019Article
- Age is a predictor of a small decrease in lung function in children with sickle cell anemia.American journal of hematology · 2018Article
- Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia.British journal of haematology · 2018Article
- Low-dose hydroxycarbamide therapy may offer similar benefit as maximum tolerated dose for children and young adults with sickle cell disease in low-middle-income settings.F1000Research · 2018Review
- Asthma Screening in Pediatric Sickle Cell Disease: A Clinic-Based Program Using Questionnaires and Spirometry.Pediatric allergy, immunology, and pulmonology · 2017Article
- Acute Chest Syndrome in Children with Sickle Cell Disease.Pediatric allergy, immunology, and pulmonology · 2017Review
- Airway Hyperresponsiveness Does Not Predict Morbidity in Children with Sickle Cell Anemia.American journal of respiratory and critical care medicine · 2017Article
Corrections and comments
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Authors and funding
13 authors at 7 institutions in 2 countries.
Funding
Abstract
objectiveTo identify factors associated with asthma associated with increased sickle cell anemia (SCA). STUDY
designChildren with SCA (N = 187; mean age 9.6 years, 48% male) were classified as having "asthma" based on parent report of physician diagnosis plus prescription of asthma medication (n = 53) or "no asthma" based on the absence of these features (n = 134). Pain and acute chest syndrome (ACS) events were collected prospectively.
resultsMultiple variable logistic regression model identified 3 factors associated with asthma: parent with asthma (P = .006), wheezing causing shortness of breath (P = .001), and wheezing after exercise (P < .001). When ≥2 features were present, model sensitivity was 100%. When none of the features were present, model sensitivity was 0%. When only 1 feature was present, model sensitivity was also 0%, and presence of ≥2 of positive allergy skin tests, airway obstruction on spirometry, and bronchodilator responsiveness did not improve clinical utility. ACS incident rates were significantly higher in individuals with asthma than in those without asthma (incident rate ratio 2.21, CI 1.31-3.76), but pain rates were not (incident rate ratio 1.28, CI 0.78-2.10).
conclusionsFor children with SCA, having a parent with asthma and specific wheezing symptoms are the best features to distinguish those with and without parent report of a physician diagnosis of asthma and to identify those at higher risk for ACS events. The value of treatment for asthma in the prevention of SCA morbidity needs to be studied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.