Evidence map›Paper›PMID 24388320›Full record

Trial reportThe Journal of pediatrics2014

Intensive care unit readmission during childhood after preterm birth with respiratory failure.

Peter M Mourani, John P Kinsella, Gilles Clermont, Lan Kong, Amy M Perkins, Lisa Weissfeld, Gary Cutter, Walter T Linde-Zwirble, Steven H Abman, Derek C Angus and 2 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Observational
  12. Article
  13. Effects of a transition home program on preterm infant emergency room visits within 90 days of discharge.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Peter M MouraniPediatric Heart Lung Center, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO. Electronic address: peter.mourani@childrenscolorado.org.
John P KinsellaPediatric Heart Lung Center, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO.
Gilles ClermontThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Lan KongThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Amy M PerkinsThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Lisa WeissfeldThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Gary CutterUniversity of Alabama, Birmingham, AL.
Walter T Linde-ZwirbleZD Associates, Perkasie, PA.
Steven H AbmanPediatric Heart Lung Center, University of Colorado School of Medicine/Children's Hospital Colorado, Aurora, CO.
Derek C AngusThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
R Scott WatsonThe CRISMA Center (Clinical Research, Investigation, and Systems Modeling of Acute Illness), Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Prolonged Outcomes after Nitric Oxide (PrONOx) Investigators
University of Pittsburgh · USUniversity of Colorado Denver · USChildren's Hospital Colorado · USUniversity of Alabama at Birmingham · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$22.1M
TISSUE INTERACTIONS IN PULMONARY VASCULAR DEVELOPMENTP50HL057144 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI STENMARK, KURT R. · 1997 to 2006
$10.0M
INHALED NO FOR THE PREVENTION OF CHRONIC LUNG DISEASEU01HL064857 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI KINSELLA, JOHN PATRICK · 2000 to 2004
$8.2M
Genetic Basis for Impaired Angiogenic Signaling in BPDR01HL085703 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT · 2008 to 2012
$3.3M
Long-Term Outcomes of NO for Ventilated Premature BabiesR01HL069991 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C · 2003 to 2007
$3.2M
NCATS NIH HHS UL1 TR001082NCRR NIH HHS M01 RR000069NCRR NIH HHS M01-RR00069NHLBI NIH HHS P50 HL057144NHLBI NIH HHS R01 HL069991NHLBI NIH HHS R01 HL085703NHLBI NIH HHS R01 HL69991NHLBI NIH HHS U01 HL064857PHS HHS P50-57144
6 · The paper itself

Abstract

objectiveTo determine the incidence and risk factors for readmission to the intensive care unit (ICU) among preterm infants who required mechanical ventilation at birth. STUDY

designWe studied preterm newborns (birth weight 500-1250 g) who required mechanical ventilation at birth and were enrolled in a multicenter trial of inhaled nitric oxide therapy. Patients were assessed up to 4.5 years of age via annual in-person evaluations and structured telephone interviews. Univariate and multivariable analyses of baseline and birth hospitalization predictors of ICU readmission were performed.

resultsOf 512 subjects providing follow-up data, 58% were readmitted to the hospital (51% of these had multiple readmissions, averaging 3.9 readmissions per subject), 19% were readmitted to an ICU, and 12% required additional mechanical ventilation support. In univariate analyses, ICU readmission was more common among male subjects (OR 2.01; 95% CI 1.27-3.18), infants with grade 3-4 intracranial hemorrhage (OR 2.13; 95% CI 1.23-3.69), increasing duration of birth hospitalization (OR 1.01 per day; 95% CI 1.00-1.02), and prolonged oxygen therapy (OR 1.01 per day; 95% CI 1.00-1.01). In the first year after birth hospitalization, children readmitted to an ICU incurred greater health care costs (median $69,700 vs $30,200 for subjects admitted to the ward and $9600 for subjects never admitted).

conclusionsSmall preterm infants who were mechanically ventilated at birth have substantial risk for readmission to an ICU and late mechanical ventilation, require extensive health care resources, and incur high treatment costs.

Indexed as

Respiration, ArtificialChild, PreschoolFemaleFollow-Up StudiesHumansInfant, NewbornInfant, PrematureIntensive Care UnitsMalePatient ReadmissionRespiratory InsufficiencyRisk Factors

Identifiers

PMID24388320
PMCPMC4522939
OpenAlexW2053920056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.