Evidence map›Paper›PMID 24388168›Full record

ArticleCell stem cell2014

HSPCs get their motors running for asymmetric fate choice.

Yi Zheng, Hartmut Geiger

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Yi ZhengDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. Electronic address: yi.zheng@cchmc.org.
Hartmut GeigerDivision of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA; Institute for Molecular Medicine, University of Ulm, Ulm 89081, Germany.

Funding

Cincinnati Center for Excellence in Molecular HematologyP30DK090971 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ZHENG, YI · 2010 to 2015
$4.0M
Lineage Determination and Tissue HomeOstasis in the aged Hematopoietic SystemR01AG040118 · NIA · CINCINNATI CHILDRENS HOSP MED CTR · PI GEIGER, HARTMUT, ZHENG, YI · 2011 to 2015
$1.7M
NIA NIH HHS R01 AG040118NIDDK NIH HHS P30 DK090971
6 · The paper itself

Abstract

Contractile forces are implicated in cell polarity and asymmetric division, but their contribution to cell fate is unclear. In this issue of Cell Stem Cell, Shin et al. (2014) show that myosin-II isoforms sense matrix stiffness in hematopoietic stem and progenitor cells, with polarized myosin-IIB promoting asymmetric self-renewal and constitutive myosin-IIA activation promoting cytokine-triggered differentiation.

Indexed as

Cell DifferentiationCell MovementHematopoiesisHematopoietic Stem CellsHumansMuscle ContractionNonmuscle Myosin Type IIANonmuscle Myosin Type IIBNonmuscle Myosin Type IIANonmuscle Myosin Type IIB

Identifiers

PMID24388168
PMCPMC3916825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.