Evidence map›Paper›PMID 24388014›Full record

ArticleStudies in history and philosophy of biological and biomedical sciences2014

The demand for pregnancy testing: the Aschheim-Zondek reaction, diagnostic versatility, and laboratory services in 1930s Britain.

Jesse Olszynko-Gryn

Open access · hybridAbstract readHistorical Article
In one paragraph

Article in Studies in history and philosophy of biological and biomedical sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
37.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

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  10. Introduction to "Working Across Species".History and philosophy of the life sciences · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jesse Olszynko-GrynDepartment of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge CB2 3RH, UK. Electronic address: jo312@cam.ac.uk.
University of Cambridge · GB

Funding

Wellcome TrustWellcome Trust 088708
6 · The paper itself

Abstract

The Aschheim-Zondek reaction is generally regarded as the first reliable hormone test for pregnancy and as a major product of the 'heroic age' of reproductive endocrinology. Invented in Berlin in the late 1920s, by the mid 1930s a diagnostic laboratory in Edinburgh was performing thousands of tests every year for doctors around Britain. In her classic history of antenatal care, sociologist Ann Oakley claimed that the Aschheim-Zondek test launched a 'modern era' of obstetric knowledge, which asserted its superiority over that of pregnant women. This article reconsiders Oakley's claim by examining how pregnancy testing worked in practice. It explains the British adoption of the test in terms less of the medicalisation of pregnancy than of clinicians' increasing general reliance on laboratory services for differential diagnosis. Crucially, the Aschheim-Zondek reaction was a test not directly for the fetus, but for placental tissue. It was used, less as a yes-or-no test for ordinary pregnancy, than as a versatile diagnostic tool for the early detection of malignant tumours and hormonal deficiencies believed to cause miscarriage. This test was as much a product of oncology and the little-explored world of laboratory services as of reproductive medicine.

Indexed as

Abortion, SpontaneousBerlinFemaleHistory, 20th CenturyHormonesHumansLaboratoriesNeoplasmsObstetricsPregnancyPregnancy TestsUnited KingdomHormonesAschheim–Zondek testClinical pathologyDiagnostic laboratoryEdinburghPregnancy hormoneReproductive endocrinology

Identifiers

PMID24388014
PMCPMC4275600
OpenAlexW2003077781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.