ArticleJournal of manipulative and physiological therapeutics2014
Neural responses to the mechanical parameters of a high-velocity, low-amplitude spinal manipulation: effect of preload parameters.
Article in Journal of manipulative and physiological therapeutics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04347551 (Motor Performance of Asymptomatic and Chronic Neck Pain Participants Pre- and Post-spinal Manipulation Using an Eye and Head Movement Fitts' Task), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Motor Performance of Asymptomatic and Chronic Neck Pain Participants Pre- and Post-spinal Manipulation Using an Eye and Head Movement Fitts' Task
Who cites it
23 citing papers in PubMed.
- Neuromechanical response to spinal manipulation therapy: effects of a constant rate of force application.BMC complementary and alternative medicine · 2016Trial
- Immediate changes after manual therapy in resting-state functional connectivity as measured by functional magnetic resonance imaging in participants with induced low back pain.Journal of manipulative and physiological therapeuticsTrial
- Technologies to investigate the mechanisms of force-based manipulations: a narrative methods review.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- The role of force-sensing devices in spinal manipulative therapy research, education, and clinical practice.The Journal of the Canadian Chiropractic Association · 2025Article
- Neuroplastic Responses to Chiropractic Care: Broad Impacts on Pain, Mood, Sleep, and Quality of Life.Brain sciences · 2024Article
- Investigating force-time characteristics of prone thoracic SMT and self-reported patient outcome measures: a feasibility study.Chiropractic & manual therapies · 2023Article
- The contemporary model of vertebral column joint dysfunction and impact of high-velocity, low-amplitude controlled vertebral thrusts on neuromuscular function.European journal of applied physiology · 2021Review
- A Systematic Review of Musculoskeletal Mobilization and Manipulation Techniques Used in Veterinary Medicine.Animals : an open access journal from MDPI · 2021Review
- Effects of Thrust Magnitude and Duration on Immediate Postspinal Manipulation Trunk Muscle Spindle Responses.Journal of manipulative and physiological therapeutics · 2021Article
- Chiropractic Spinal Manipulation Prevents Secondary Hyperalgesia Induced by Topical Capsaicin in Healthy Individuals.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Force Distribution Within Spinal Tissues During Posterior to Anterior Spinal Manipulative Therapy: A Secondary Analysis.Frontiers in integrative neuroscience · 2021Article
- Differences in force-time parameters and electromyographic characteristics of two high-velocity, low-amplitude spinal manipulations following one another in quick succession.Chiropractic & manual therapies · 2020Article
- Assessing forces during spinal manipulation and mobilization: factors influencing the difference between forces at the patient-table and clinician-patient interfaces.Chiropractic & manual therapies · 2020Article
- Physiological Responses Induced by Manual Therapy in Animal Models: A Scoping Review.Frontiers in neuroscience · 2020Article
- Spinal manipulation frequency and dosage effects on clinical and physiological outcomes: a scoping review.Chiropractic & manual therapies · 2019Article
- The epidemiology of work-related musculoskeletal injuries among chiropractors in the eThekwini municipality.Chiropractic & manual therapies · 2019Article
- Article
- Spinal Tissue Loading Created by Different Methods of Spinal Manipulative Therapy Application.Spine · 2017Article
- Neural responses to the mechanical characteristics of high velocity, low amplitude spinal manipulation: Effect of specific contact site.Manual therapy · 2015Article
- Neural Response During a Mechanically Assisted Spinal Manipulation in an Animal Model: A Pilot Study.Journal of novel physiotherapy and physical rehabilitation · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe purpose of this study was to determine how the preload that precedes a high-velocity, low-amplitude spinal manipulation (HVLA-SM) affects muscle spindle input from lumbar paraspinal muscles both during and after the HVLA-SM.
methodsPrimary afferent activity from muscle spindles in lumbar paraspinal muscles were recorded from the L6 dorsal root in anesthetized cats. High-velocity, low-amplitude spinal manipulation of the L6 vertebra was preceded either by no preload or systematic changes in the preload magnitude, duration, and the presence or absence of a downward incisural point. Immediate effects of preload on muscle spindle responses to the HVLA-SM were determined by comparing mean instantaneous discharge frequencies (MIF) during the HVLA-SM's thrust phase with baseline. Longer lasting effects of preload on spindle responses to the HVLA-SM were determined by comparing MIF during slow ramp and hold movement of the L6 vertebra before and after the HVLA-SM.
resultsThe smaller compared with the larger preload magnitude and the longer compared with the shorter preload duration significantly increased (P = .02 and P = .04, respectively) muscle spindle responses during the HVLA-SM thrust. The absence of preload had the greatest effect on the change in MIF. Interactions between preload magnitude, duration, and downward incisural point often produced statistically significant but arguably physiologically modest changes in the passive signaling properties of the muscle spindle after the manipulation.
conclusionBecause preload parameters in this animal model were shown to affect neural responses to an HVLA-SM, preload characteristics should be taken into consideration when judging this intervention's therapeutic benefit in both clinical efficacy studies and in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.