ArticleBiological psychiatry2014
Major depressive disorder is associated with abnormal interoceptive activity and functional connectivity in the insula.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 215 papers, 9 of them syntheses that pooled it.
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Who cites it
215 citing papers in PubMed, 9 syntheses or guidelines pooled it, 433 citations in OpenAlex.
- Comparative effectiveness and dose-response relationships of exercise for depressive symptoms in children and adolescents: a Bayesian network meta-analysis.BMC psychiatry · 2026Pooled it
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- The Effectiveness of Mindfulness-Based Interventions for Depressive Symptoms and Their Relationship to Interoceptive Awareness: A Systematic Review.Alpha psychiatry · 2025Pooled it
- Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Pooled it
- Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis.Molecular psychiatry · 2017Pooled it
- Conjoint and dissociated structural and functional abnormalities in first-episode drug-naive patients with major depressive disorder: a multimodal meta-analysis.Scientific reports · 2017Pooled it
- Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Pooled it
- High-order brain interactions during ketamine-induced state changes: A functional marker of response in late-life treatment-resistant depression?Translational psychiatry · 2026Trial
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- General and anxiety-linked influences of acute serotonin reuptake inhibition on neural responses associated with attended visceral sensation.Translational psychiatry · 2024Trial
- Trial
- Single doses of a highly selective inhibitor of phosphodiesterase 1 (lenrispodun) in healthy volunteers: a randomized pharmaco-fMRI clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- A double-blind placebo-controlled trial of minocycline on translocator protein distribution volume in treatment-resistant major depressive disorder.Translational psychiatry · 2021Trial
- Losing trust in body sensations: Interoceptive awareness and depression symptom severity among primary care patients.Journal of affective disorders · 2021Trial
- Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex.Science China. Life sciences · 2021Trial
- Attentional bias modification is associated with fMRI response toward negative stimuli in individuals with residual depression: a randomized controlled trialJournal of psychiatry & neuroscience : JPN · 2020Trial
- Default Mode Connectivity in Major Depressive Disorder Measured Up to 10 Days After Ketamine Administration.Biological psychiatry · 2018Trial
- Group differences in MEG-ICA derived resting state networks: Application to major depressive disorder.NeuroImage · 2015Trial
155 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundSomatic complaints and altered interoceptive awareness are common features in the clinical presentation of major depressive disorder (MDD). Recently, neurobiological evidence has accumulated demonstrating that the insula is one of the primary cortical structures underlying interoceptive awareness. Abnormal interoceptive representation within the insula may thus contribute to the pathophysiology and symptomatology of MDD.
methodsWe compared functional magnetic resonance imaging blood oxygenation level-dependent responses between 20 unmedicated adults with MDD and 20 healthy control participants during a task requiring attention to visceral interoceptive sensations and also assessed the relationship of this blood oxygenation level-dependent response to depression severity, as rated using the Hamilton Depression Rating Scale. Additionally, we examined between-group differences in insula resting-state functional connectivity and its relationship to Hamilton Depression Rating Scale ratings of depression severity.
resultsRelative to the healthy control subjects, unmedicated MDD subjects exhibited decreased activity bilaterally in the dorsal mid-insula cortex (dmIC) during interoception. Activity within the insula during the interoceptive attention task was negatively correlated with both depression severity and somatic symptom severity in depressed subjects. Major depressive disorder also was associated with greater resting-state functional connectivity between the dmIC and limbic brain regions implicated previously in MDD, including the amygdala, subgenual prefrontal cortex, and orbitofrontal cortex. Moreover, functional connectivity between these regions and the dmIC was positively correlated with depression severity.
conclusionsMajor depressive disorder and the somatic symptoms of depression are associated with abnormal interoceptive representation within the insula.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.