Evidence map›Paper›PMID 24387311›Full record

ArticleAlzheimer's research & therapy2014

Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

Sivaraman Purushothuman, Daniel M Johnstone, Charith Nandasena, John Mitrofanis, Jonathan Stone

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 80 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 3 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03405662 nacompletednot on this mapstarted 2018, after this paper: background citation

Examining the Impact of Photobiomodulation on Cognition, Behavior, and Biomarkers of Alzheimer's Disease

TypeinterventionalSponsorUniversity of California, San FranciscoRan2018 to 2021Enrolled23ConditionsAlzheimer DiseaseArmsVielight Neuro Gamma, Sham Vielight Neuro Gamma
NCT06352372 phase2completednot on this mapstarted 2024, after this paper: background citation

Safety and Efficacy of Transcranial Photobiomodulation (tPBM) for Individuals With Autism Spectrum Disorder and Epileptiform Activity

TypeinterventionalSponsorRichard FryeRan2024 to 2026Enrolled6ConditionsAutism Spectrum Disorder, EEG With Periodic Abnormalities, Epilepsy, Neurodevelopmental DisordersArmsnoninvasively delivered near infra-red (NIR) light - transcranial Photobiomodulation (tPBM)
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 3 syntheses or guidelines pooled it, 163 citations in OpenAlex.

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20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sivaraman PurushothumanBosch Institute, University of Sydney NSW 2006, Australia ; Discipline of Physiology, Anderson Stuart Building F13, University of Sydney NSW 2006, Australia.
Daniel M JohnstoneBosch Institute, University of Sydney NSW 2006, Australia ; Discipline of Physiology, Anderson Stuart Building F13, University of Sydney NSW 2006, Australia.
Charith NandasenaBosch Institute, University of Sydney NSW 2006, Australia ; Discipline of Physiology, Anderson Stuart Building F13, University of Sydney NSW 2006, Australia.
John MitrofanisBosch Institute, University of Sydney NSW 2006, Australia ; Discipline of Anatomy & Histology, Anderson Stuart Building F13, University of Sydney NSW 2006, Australia.
Jonathan StoneBosch Institute, University of Sydney NSW 2006, Australia ; Discipline of Physiology, Anderson Stuart Building F13, University of Sydney NSW 2006, Australia.
University of Sydney · AURobert Bosch (Australia) · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrevious work has demonstrated the efficacy of irradiating tissue with red to infrared light in mitigating cerebral pathology and degeneration in animal models of stroke, traumatic brain injury, parkinsonism and Alzheimer's disease (AD). Using mouse models, we explored the neuroprotective effect of near infrared light (NIr) treatment, delivered at an age when substantial pathology is already present in the cerebral cortex.

methodsWe studied two mouse models with AD-related pathologies: the K369I tau transgenic model (K3), engineered to develop neurofibrillary tangles, and the APPswe/PSEN1dE9 transgenic model (APP/PS1), engineered to develop amyloid plaques. Mice were treated with NIr 20 times over a four-week period and histochemistry was used to quantify AD-related pathological hallmarks and other markers of cell damage in the neocortex and hippocampus.

resultsIn the K3 mice, NIr treatment was associated with a reduction in hyperphosphorylated tau, neurofibrillary tangles and oxidative stress markers (4-hydroxynonenal and 8-hydroxy-2'-deoxyguanosine) to near wildtype levels in the neocortex and hippocampus, and with a restoration of expression of the mitochondrial marker cytochrome c oxidase in surviving neurons. In the APP/PS1 mice, NIr treatment was associated with a reduction in the size and number of amyloid-β plaques in the neocortex and hippocampus.

conclusionsOur results, in two transgenic mouse models, suggest that NIr may have potential as an effective, minimally-invasive intervention for mitigating, and even reversing, progressive cerebral degenerations.

Identifiers

PMID24387311
PMCPMC3978916
OpenAlexW2004719140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.