Evidence map›Paper›PMID 24386640›Full record

Trial reportBioMed research international2013

Pediatric tuberculosis in young children in India: a prospective study.

Sanjay K Jain, Alvaro Ordonez, Aarti Kinikar, Nikhil Gupte, Madhuri Thakar, Vidya Mave, Jennifer Jubulis, Sujata Dharmshale, Shailaja Desai, Swarupa Hatolkar and 4 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 90 citations in OpenAlex.

  1. Pooled it
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  17. Radiosynthesis and PET Bioimaging ofACS infectious diseases · 2019
    Article
  18. Article
  19. Imaging in Pediatric Extra-Pulmonary Tuberculosis.Indian journal of pediatrics · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Sanjay K JainDepartment of Pediatrics, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA ; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA ; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA.
Alvaro OrdonezDepartment of Pediatrics, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA ; Center for Tuberculosis Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA ; Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA.
Aarti KinikarByramjee Jeejeebhoy Government Medical College, Pune, India.
Nikhil GupteByramjee Jeejeebhoy Government Medical College, Pune, India ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Madhuri ThakarNational AIDS Research Institute, Pune, India.
Vidya MaveByramjee Jeejeebhoy Government Medical College, Pune, India ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jennifer JubulisDepartment of Pediatrics, Johns Hopkins University School of Medicine, 1550 Orleans Street, CRB-II, Room 1.09, Baltimore, MD 21287, USA.
Sujata DharmshaleByramjee Jeejeebhoy Government Medical College, Pune, India.
Shailaja DesaiByramjee Jeejeebhoy Government Medical College, Pune, India.
Swarupa HatolkarByramjee Jeejeebhoy Government Medical College, Pune, India.
Anju KagalByramjee Jeejeebhoy Government Medical College, Pune, India.
Ajit LalvaniImperial College London, London, UK.
Amita GuptaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Renu BharadwajByramjee Jeejeebhoy Government Medical College, Pune, India.
Government Medical College · INJohns Hopkins University · USImperial College London · GBJohns Hopkins Medicine · USNational AIDS Research Institute · IN

Funding

Byramee Jeejeebhoy Medical College (BJMC), Pune, India: Clinical Trials UnitU01AI069497 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GUPTA, AMITA · 2007 to 2011
$4.1M
Novel imaging biomarkers to address fundamental controversies in TB pathogenesisDP2OD006492 · OD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2014
$2.9M
Diagnosis of active TB in HIV infected and uninfected young children in IndiaR03HD061059 · NICHD · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2009 to 2010
$132k
NIAID NIH HHS 5U01AI069497NIAID NIH HHS U01 AI069497NICHD NIH HHS R03 HD061059NICHD NIH HHS R03 HD061059-01NIH HHS DP2 OD006492NIH HHS OD006492
6 · The paper itself

Abstract

backgroundIndia has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes.

methodsYoung children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital in Pune, India. Detailed clinical evaluation, HIV testing, mycobacterial cultures, and drug susceptibility testing were performed.

results223 children with suspected TB were enrolled. The median age was 31 months, 46% were female, 86% had received BCG, 57% were malnourished, and 10% were HIV positive. 12% had TB disease (definite or probable), 35% did not have TB, while TB could not be ruled out in 53%. Extrapulmonary disease was noted in 46%, which was predominantly meningeal. Tuberculin skin test (TST) was positive in 20% of children with TB. Four of 7 (57%) children with culture-confirmed TB harbored drug-resistant (DR) strains of whom 2 (50%) were multi-DR (MDR). In adjusted analyses, HIV infection, positive TST, and exposure to household smoke were found to be significantly associated with children with TB (P ≤ 0.04). Mortality (at 1 year) was 3 of 26 (12%) and 1 of 79 (1%), respectively, in children with TB and those without TB (P < 0.05).

conclusionsDiagnosis of TB is challenging in young children, with high rates of extra-pulmonary and meningeal disease. While the data on DR-TB are limited by the small sample size, they are however concerning, and additional studies are needed to more accurately define the prevalence of DR strains in this vulnerable population.

Indexed as

Tuberculosis, MeningealTuberculosis, Multidrug-ResistantChild, PreschoolDisease-Free SurvivalFemaleHIV InfectionsHumansIndiaInfantMalePrevalenceProspective StudiesSurvival RateTertiary Care CentersTuberculin Test

Identifiers

PMID24386640
PMCPMC3872373
OpenAlexW2013086342

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.