Evidence map›Paper›PMID 24386635›Full record

ArticleBioMed research international2013

Merit of anisodamine combined with opioid δ-receptor activation in the protection against myocardial injury during cardiopulmonary bypass.

Xuan Hong, Huimin Fan, Rong Lu, Paul Chan, Zhongmin Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Xuan HongDepartment of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China.
Huimin FanDepartment of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China.
Rong LuDepartment of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China.
Paul ChanDepartment of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China ; Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, 111 Hsin-Lung Road, Section 3, Taipei 116, Taiwan.
Zhongmin LiuDepartment of Cardiothoracic Surgery, Shanghai East Hospital, Tongji University, 150 Jimo Road, Shanghai 200120, China.
Shanghai East Hospital · CNTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial ischemia/reperfusion (MIR) injury easily occurrs during cardiopulmonary bypass surgery in elderly patients. In an attempt to develop an effective strategy, we employed a pig model of MIR injury to investigate the maximum rate of change of left ventricular pressure, left ventricular enddiastolic pressure, and left intraventricular pressure. Coronary sinus cardiac troponin T (TnT) and adenosine-triphosphate (ATP) content in myocardium were measured. The ultrastructures for MIR injury were visualized by transmission electron microscopy (TEM). The role of δ-opioid receptor activation using D-Ala2, D-Leu5-enkephalin (DADLE) in both early (D1) and late (D2) phases of cardioprotection was identified. Also, the merit of cardioprotection by DADLE in combination with anisodamine, the muscarinic receptor antagonist (D+M), was evaluated. Glibenclamide was employed at the dose sufficient to block ATP-sensitive potassium channels. Significant higher cardiac indicators, reduced TnT and increased ATP contents, were observed in D1, D2, and D+M groups compared with the control group. DADLE induced protection was better in later phase of ischemia that was attenuated by glibenclamide. DADLE after the ischemia showed no benefit, but combined treatment with anisodamine showed a marked postischemic cardioprotection. Thus, anisodamine is helpful in combination with DADLE for postischemic cardioprotection.

Indexed as

Adenosine TriphosphateAnimalsCardiopulmonary BypassCell ShapeCoronary SinusGTP-Binding Protein alpha Subunits, Gi-GoHeart Function TestsMyocardial Reperfusion InjuryMyocardiumProtein Kinase CReceptors, Opioid, deltaSolanaceous AlkaloidsSus scrofaTroponinAdenosine TriphosphateanisodamineGTP-Binding Protein alpha Subunits, Gi-GoProtein Kinase CReceptors, Opioid, deltaSolanaceous AlkaloidsTroponin

Identifiers

PMID24386635
PMCPMC3872392
OpenAlexW2008238605

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.