ArticleOxidative medicine and cellular longevity2013
Early growth response protein 1 promotes restenosis by upregulating intercellular adhesion molecule-1 in vein graft.
Article in Oxidative medicine and cellular longevity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Early growth response-1, a dynamic conduit in cardiovascular disease.Frontiers in cardiovascular medicine · 2024Review
- Early Growth Response-1, an Integrative Sensor in Cardiovascular and Inflammatory Disease.Journal of the American Heart Association · 2021Review
- The Protective Effects of Benzbromarone Against Propofol-Induced Inflammation and Injury in Human Brain Microvascular Endothelial Cells (HBMVECs).Neurotoxicity research · 2021Article
- Corrigendum to "Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft".Oxidative medicine and cellular longevity · 2021Article
- Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress.Cardiology research and practice · 2020Article
- Hyperglycaemia cause vascular inflammation through advanced glycation end products/early growth response-1 axis in gestational diabetes mellitus.Molecular and cellular biochemistry · 2019Article
- Designed Surface Topographies Control ICAM-1 Expression in Tonsil-Derived Human Stromal Cells.Frontiers in bioengineering and biotechnology · 2018Article
- Article
- P2X7R antagonism after subfailure overstretch injury of blood vessels reverses vasomotor dysfunction and prevents apoptosis.Purinergic signalling · 2017Article
- MiR-551b-5p Contributes to Pathogenesis of Vein Graft Failure via Upregulating Early Growth Response-1 Expression.Chinese medical journal · 2017Article
- Early growth response-1 in the pathogenesis of cardiovascular disease.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Mechanical stretch: physiological and pathological implications for human vascular endothelial cells.Vascular cell · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo verify the relationship between Egr-1 and vein graft restenosis and investigate the related mechanisms.
methodsMouse vein graft models were established in Egr-1 knockout (KO) and wild-type (WT) mice. The vein grafts in the mice were taken for pathological examination and immunohistochemical analysis. The endothelial cells (ECs) were stimulated by using a computer-controlled cyclic stress unit. BrdU staining and PCR were used to detect ECs proliferation activity and Egr-1 and ICAM-1 mRNA expression, respectively. Western-blot analysis was also used to detect expression of Egr-1 and intercellular adhesion molecule-1 (ICAM-1) proteins.
resultsThe lumens of vein grafts in Egr-1 KO mice were wider than in WT mice. ECs proliferation after mechanical stretch stimulation was suppressed by Egr-1 knockout (P < 0.05). Both in vein grafts and ECs from WT mice after mechanical stretch stimulation, mRNA expression and protein of Egr-1 and ICAM-1 showed increases (P < 0.05). However, ICAM-1 expression was significantly suppressed in ECs from Egr-1 knockout mice (P < 0.05).
conclusionsEgr-1 may promote ECs proliferation and result in vein graft restenosis by upregulating the expression of ICAM-1. As a key factor of vein graft restenosis, it could be a target for the prevention of restenosis after CABG surgery.
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