Evidence map›Paper›PMID 24386489›Full record

Trial reportPloS one2013

Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis.

Rian M Nijmeijer, Hjalmar C van Santvoort, Alexandra Zhernakova, Steffen Teller, Jonas A Scheiber, Carolien G de Kovel, Marc G H Besselink, Jeroen T J Visser, Femke Lutgendorff, Thomas L Bollen and 9 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Genetic Polymorphisms: A Novel Perspective on Acute Pancreatitis.Gastroenterology research and practice · 2017
    Review
  7. Review
  8. Genetics and treatment options for recurrent acute and chronic pancreatitis.Current treatment options in gastroenterology · 2014
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Rian M NijmeijerDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Hjalmar C van SantvoortDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Alexandra ZhernakovaComplex Genetics Group, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Steffen TellerDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Jonas A ScheiberDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Carolien G de KovelComplex Genetics Group, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Marc G H BesselinkDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands ; Department of Surgery, Academic Medical Center, Amsterdam, the Netherlands.
Jeroen T J VisserDepartment of Cell Biology, Immunology Section, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Femke LutgendorffDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Thomas L BollenDepartment of Radiology, St Antonius Hospital, Nieuwegein, the Netherlands.
Marja A BoermeesterDepartment of Surgery, Academic Medical Center, Amsterdam, the Netherlands.
Ger T RijkersDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands ; Department of Operating Room/Evidence Based Surgery, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands ; Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, the Netherlands.
Frank U WeissDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Julia MayerleDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Markus M LerchDepartment of Internal Medicine A, Ernst-Moritz-Arndt University, Greifswald, Germany.
Hein G GooszenDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands ; Department of Operating Room/Evidence Based Surgery, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands.
Louis M A AkkermansDepartment of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Cisca WijmengaComplex Genetics Group, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Dutch Pancreatitis Study Group
Universität Greifswald · DEUniversity Medical Center Utrecht · NLAcademic Medical Center · NLRadboud University Nijmegen · NLUniversity Medical Center Groningen · NLSt. Antonius Ziekenhuis · NLUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionImpairment of the mucosal barrier plays an important role in the pathophysiology of acute pancreatitis. The myosin IXB (MYO9B) gene and the two tight-junction adaptor genes, PARD3 and MAGI2, have been linked to gastrointestinal permeability. Common variants of these genes are associated with celiac disease and inflammatory bowel disease, two other conditions in which intestinal permeability plays a role. We investigated genetic variation in MYO9B, PARD3 and MAGI2 for association with acute pancreatitis.

methodsFive single nucleotide polymorphisms (SNPs) in MYO9B, two SNPs in PARD3, and three SNPs in MAGI2 were studied in a Dutch cohort of 387 patients with acute pancreatitis and over 800 controls, and in a German cohort of 235 patients and 250 controls.

resultsAssociation to MYO9B and PARD3 was observed in the Dutch cohort, but only one SNP in MYO9B and one in MAGI2 showed association in the German cohort (p < 0.05). Joint analysis of the combined cohorts showed that, after correcting for multiple testing, only two SNPs in MYO9B remained associated (rs7259292, p = 0.0031, odds ratio (OR) 1.94, 95% confidence interval (95% CI) 1.35-2.78; rs1545620, p = 0.0006, OR 1.33, 95% CI 1.16-1.53). SNP rs1545620 is a non-synonymous SNP previously suspected to impact on ulcerative colitis. None of the SNPs showed association to disease severity or etiology.

conclusionVariants in MYO9B may be involved in acute pancreatitis, but we found no evidence for involvement of PARD3 or MAGI2.

Indexed as

Polymorphism, Single NucleotideAcute DiseaseAdaptor Proteins, Signal TransducingAdultAgedCarrier ProteinsCell Cycle ProteinsCohort StudiesFemaleGermanyGuanylate KinasesHumansMaleMembrane ProteinsMiddle AgedMyosinsAdaptor Proteins, Signal TransducingCarrier ProteinsCell Cycle ProteinsGuanylate KinasesMAGI2 protein, humanMembrane Proteinsmyosin IXBMyosinsPARD3 protein, human

Identifiers

PMID24386489
PMCPMC3875581
OpenAlexW2157005147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.