ArticlePloS one2013
Transcriptomic analysis of brown adipose tissue across the physiological extremes of natural hibernation.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Depot-Specific White Adipose Tissue Remodeling Supports Non-Thermogenic Metabolic Homeostasis During Shallow Hibernation in Raccoon Dogs.International journal of molecular sciences · 2026Article
- Mechanisms of energy metabolism reprogramming and homeostasis maintenance in overwintering hibernating animals.Frontiers in veterinary science · 2026Review
- Burning fast & slow: a review of the differential metabolic routes of brown adipose tissue activity during cold exposure and their implications for populational variation.Lipids in health and disease · 2025Review
- Mitochondrial-derived gene expression in hibernation: tissue-specific responses in the thirteen-lined ground squirrel.Open biology · 2025Article
- Mitochondrial proteomic adaptations to daily torpor in the Djungarian hamster (Phodopus sungorus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Orphan nuclear receptor NR4A1 regulates both osteoblastogenesis and adipogenesis in human mesenchymal stem cells.Molecular medicine reports · 2025Article
- Gene regulatory changes underlie developmental plasticity in respiration and aerobic performance in highland deer mice.Molecular ecology · 2023Article
- Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound.Nature metabolism · 2023Article
- Mass spectrometry of the white adipose metabolome in a hibernating mammal reveals seasonal changes in alternate fuels and carnitine derivatives.Frontiers in physiology · 2023Article
- The Gut Microbiota Metabolite Succinate Promotes Adipose Tissue Browning in Crohn's Disease.Journal of Crohn's & colitis · 2022Article
- Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes.Nature communications · 2022Article
- Hibernation slows epigenetic ageing in yellow-bellied marmots.Nature ecology & evolution · 2022Article
- The role of neutral and adaptive genomic variation in population diversification and speciation in two ground squirrel species of conservation concern.Molecular ecology · 2021Article
- Transcriptome Analysis Reveals Genes Involved in Thermogenesis in Two Cold-Exposed Sheep Breeds.Genes · 2021Article
- Multi-omics analysis reveals that natural hibernation is crucial for oocyte maturation in the female Chinese alligator.BMC genomics · 2020Article
- Cytoprotection by a naturally occurring variant of ATP5G1 in Arctic ground squirrel neural progenitor cells.eLife · 2020Article
- A Unique Energy-Saving Strategy during Hibernation Revealed by Multi-Omics Analysis in the Chinese Alligator.iScience · 2020Article
- Vertebrate diapause preserves organisms long term through Polycomb complex members.Science (New York, N.Y.) · 2020Article
- The Effects of Graded Levels of Calorie Restriction: XIV. Global Metabolomics Screen Reveals Brown Adipose Tissue Changes in Amino Acids, Catecholamines, and Antioxidants After Short-Term Restriction in C57BL/6 Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- The Torpid State: Recent Advances in Metabolic Adaptations and Protective MechanismsFrontiers in physiology · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We used RNAseq to generate a comprehensive transcriptome of Brown Adipose Tissue (BAT) over the course of a year in the naturally hibernating thirteen-lined ground squirrel, Ictidomys tridecemlineatus. During hibernation ground squirrels do not feed and use fat stored in White Adipose Tissue (WAT) as their primary source of fuel. Stored lipid is consumed at high rates by BAT to generate heat at specific points during the hibernation season. The highest rate of BAT activity occurs during periodic arousals from hypothermic torpor bouts, referred to as Interbout Arousals (IBAs). IBAs are characterized by whole body re-warming (from 5 to 37 °C) in 2-3 hours, and provide a unique opportunity to determine the genes responsible for the highly efficient lipid oxidation and heat generation that drives the arousal process. Illumina HighSeq sequencing identified 14,573 distinct BAT mRNAs and quantified their levels at four points: active ground squirrels in April and October, and hibernating animals during both torpor and IBA. Based on significant changes in mRNA levels across the four collection points, 2,083 genes were shown to be differentially expressed. In addition to providing detail on the expression of nuclear genes encoding mitochondrial proteins, and genes involved in beta-adrenergic and lipolytic pathways, we identified differentially expressed genes encoding various transcription factors and other regulatory proteins which may play critical roles in high efficiency fat catabolism, non-shivering thermogenesis, and transitions into and out of the torpid state.
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