ArticlePloS one2013
Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- HeterogeneousJournal of medical microbiology · 2025Article
- Profiling Salmonella transcriptional dynamics during macrophage infection using a comprehensive reporter library.Nature microbiology · 2025Article
- Deletion ofFrontiers in microbiology · 2023Article
- The Biological Significance of Pyruvate Sensing and Uptake inMicroorganisms · 2022Article
- New Roles for Two-Component System Response Regulators ofMicroorganisms · 2020Article
- Review
- Identification of a High-Affinity Pyruvate Receptor in Escherichia coli.Scientific reports · 2017Article
- Review
- Comparative analysis of LytS/LytTR-type histidine kinase/response regulator systems in γ-proteobacteria.PloS one · 2017Article
- Variation at HLA-DRB1 is associated with resistance to enteric fever.Nature genetics · 2014Article
Corrections and comments
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Authors and funding
19 authors at 7 institutions in 5 countries.
Funding
Abstract
Proteins exhibiting hyper-variable sequences within a bacterial pathogen may be associated with host adaptation. Several lineages of the monophyletic pathogen Salmonella enterica serovar Typhi (S. Typhi) have accumulated non-synonymous mutations in the putative two-component regulatory system yehUT. Consequently we evaluated the function of yehUT in S. Typhi BRD948 and S. Typhimurium ST4/74. Transcriptome analysis identified the cstA gene, encoding a carbon starvation protein as the predominantly yehUT regulated gene in both these serovars. Deletion of yehUT had no detectable effect on the ability of these mutant Salmonella to invade cultured epithelial cells (S. Typhi and S. Typhimurium) or induce colitis in a murine model (S. Typhimurium only). Growth, metabolic and antimicrobial susceptibility tests identified no obvious influences of yehUT on these phenotypes.
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Registered trials
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