ArticlePloS one2013
Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of Fibulin-5 Gene Silencing on Proliferation and Apoptosis of IgG4-ROD Lacrimal Gland Fibroblasts.Stem cells international · 2023Article
- Upregulation of CEP55 Predicts Dismal Prognosis in Patients with Liver Cancer.BioMed research international · 2020Article
- Article
- microRNA-613 exerts anti-angiogenic effect on nasopharyngeal carcinoma cells through inactivating the AKT signaling pathway by down-regulating FN1.Bioscience reports · 2019Article
- CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer.EMBO molecular medicine · 2018Article
- High levels of centrosomal protein 55 expression is associated with poor clinical prognosis in patients with cervical cancer.Oncology letters · 2018Article
- CEP55 promotes the proliferation, migration and invasion of esophageal squamous cell carcinoma via the PI3K/Akt pathway.OncoTargets and therapy · 2018Article
- Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A.Scientific reports · 2017Article
- Identification of specific biomarkers for gastric adenocarcinoma by ITRAQ proteomic approach.Scientific reports · 2016Article
- Hypoxia and Transforming Growth Factor β Cooperate to Induce Fibulin-5 Expression in Pancreatic Cancer.The Journal of biological chemistry · 2016Article
- Avoiding hepatic metastasis naturally: Lessons from the cotton top tamarin (Saguinus oedipus).World journal of gastroenterology · 2016Review
- Upregulation of centrosomal protein 55 is associated with unfavorable prognosis and tumor invasion in epithelial ovarian carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Review
- Circulating CD105 shows significant impact in patients of oral cancer and promotes malignancy of cancer cells via CCL20.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Centrosomal Protein of 55 Regulates Glucose Metabolism, Proliferation and Apoptosis of Glioma Cells via the Akt/mTOR Signaling Pathway.Journal of Cancer · 2016Article
- Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification.OncoTargets and therapy · 2016Article
- Effect of fibulin-5 on adhesion, migration and invasion of hepatocellular carcinoma cells via an integrin-dependent mechanism.World journal of gastroenterology · 2015Article
- Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer.Oncotarget · 2015Article
- Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer.Molecular cancer · 2015Article
- Fibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expression.BMC cancer · 2014Article
Corrections and comments
- Retraction · 2020-01-09Contamination of Cell Lines/Tissues · Copyright Claims · Error in Image · Manipulation of Images · Original Data and/or Images not Provided and/or not Available · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNasopharyngeal carcinoma (NPC) is known for its high metastatic potential and locoregional recurrence, although the molecular alterations that are driving NPC metastasis remain unclear at this time. This study aimed to examine the expression of fibulin-5 in NPC, correlate the results with clinicopathological variables and survival, and to investigate the role of fibulin-5 in human NPC cell lines. MATERIAL AND
methodsStandard semi-quantitative-RT-PCR, quantitative-RT-PCR, immunoblotting, and immunohistochemistry were used to investigate the mRNA and protein expression profiles of fibulin-5 in normal and NPC tissues. Immunohistochemistry of fibulin-5 was correlated with clinicopathological characteristics by univariate analyses. NPC cells overexpressing fibulin-5 or fibulin-5-siRNA cells were generated by stable transfection to characterize the molecular mechanisms of fibulin-5-elicited cell growth and metastasis.
resultsOur results demonstrated that fibulin-5 overexpression in NPC specimens and significantly correlated with advanced tumor metastasis indicating a poor 5-year overall survival. Fibulin-5 was mainly expressed in the nucleus in human NPC specimens and cell lines. Functionally, fibulin-5 overexpression yielded fast growth in NPC cells. In addition, fibulin-5 promotes cell metastasis in NPC cells through increased FLJ10540 and phosphor-AKT activity. In contrast, siRNA depletion of fibulin-5 suppressed FLJ10540 expression and phosphor-AKT activity. Suppression of either fibulin-5 or FLJ10540 can cause significant inhibition with regards to cell motility in NPC cells. Finally, immunohistochemical analysis of human aggressive NPC specimens showed a significant and positive correlation between fibulin-5 and FLJ10540 expression.
conclusionHigher fibulin-5 expression is not only an important indicator of poor survival, but also contributes to the development of new therapeutic strategies in the FLJ10540/AKT pathway for NPC treatment.
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