ArticlePloS one2013
Characterizing the infection-induced transcriptome of Nasonia vitripennis reveals a preponderance of taxonomically-restricted immune genes.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Current Knowledge on Bee Innate Immunity Based on Genomics and Transcriptomics.International journal of molecular sciences · 2022Review
- Identification of the Gene Repertoire of the IMD Pathway and Expression of Antimicrobial Peptide Genes in Several Tissues and Hemolymph of the CockroachInternational journal of molecular sciences · 2022Article
- The genome of the stable fly, Stomoxys calcitrans, reveals potential mechanisms underlying reproduction, host interactions, and novel targets for pest control.BMC biology · 2021Article
- Sawfly Genomes Reveal Evolutionary Acquisitions That Fostered the Mega-Radiation of Parasitoid and Eusocial Hymenoptera.Genome biology and evolution · 2020Article
- Effector specificity and function in Drosophila innate immunity: Getting AMPed and dropping Boms.PLoS pathogens · 2020Review
- Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis.PLoS genetics · 2020Article
- Comparative genomics of the miniature wasp and pest control agent Trichogramma pretiosum.BMC biology · 2018Article
- Taxonomically Restricted Genes Are Fundamental to Biology and Evolution.Frontiers in genetics · 2018Article
- Proteomics ofPeerJ · 2018Article
- Embryo Microinjection and Transplantation Technique for Nasonia vitripennis Genome Manipulation.Journal of visualized experiments : JoVE · 2017Article
- Generation of heritable germline mutations in the jewel wasp Nasonia vitripennis using CRISPR/Cas9.Scientific reports · 2017Article
- Rapid Expansion of Immune-Related Gene Families in the House Fly, Musca domestica.Molecular biology and evolution · 2017Article
- OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis.BMC genomics · 2016Article
- Disentangling a Holobiont - Recent Advances and Perspectives inFrontiers in microbiology · 2016Review
- Evolutionary genetics of insect innate immunity.Briefings in functional genomics · 2015Review
- Oviposition but Not Sex Allocation Is Associated with Transcriptomic Changes in Females of the Parasitoid Wasp Nasonia vitripennis.G3 (Bethesda, Md.) · 2015Article
- Scrutinizing the immune defence inventory of Camponotus floridanus applying total transcriptome sequencing.BMC genomics · 2015Article
- Genetic and epigenetic architecture of sex-biased expression in the jewel wasps Nasonia vitripennis and giraulti.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- We can't all be supermodels: the value of comparative transcriptomics to the study of non-model insects.Insect molecular biology · 2015Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The innate immune system in insects consists of a conserved core signaling network and rapidly diversifying effector and recognition components, often containing a high proportion of taxonomically-restricted genes. In the absence of functional annotation, genes encoding immune system proteins can thus be difficult to identify, as homology-based approaches generally cannot detect lineage-specific genes. Here, we use RNA-seq to compare the uninfected and infection-induced transcriptome in the parasitoid wasp Nasonia vitripennis to identify genes regulated by infection. We identify 183 genes significantly up-regulated by infection and 61 genes significantly down-regulated by infection. We also produce a new homology-based immune catalog in N. vitripennis, and show that most infection-induced genes cannot be assigned an immune function from homology alone, suggesting the potential for substantial novel immune components in less well-studied systems. Finally, we show that a high proportion of these novel induced genes are taxonomically restricted, highlighting the rapid evolution of immune gene content. The combination of functional annotation using RNA-seq and homology-based annotation provides a robust method to characterize the innate immune response across a wide variety of insects, and reveals significant novel features of the Nasonia immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.