ArticlePloS one2013
Assessing the role of cell-surface molecules in central synaptogenesis in the Drosophila visual system.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 41 citations in OpenAlex.
- Synaptic promiscuity in brain development.Current biology : CB · 2024Review
- SynLight: a bicistronic strategy for simultaneous active zone and cell labeling in the Drosophila nervous system.G3 (Bethesda, Md.) · 2023Article
- SynLight: a dicistronic strategy for simultaneous active zone and cell labeling in thebioRxiv : the preprint server for biology · 2023Article
- Axon-axon interactions determine modality-specific wiring and subcellular synaptic specificity in a somatosensory circuit.Development (Cambridge, England) · 2023Article
- Synaptic Development in Diverse Olfactory Neuron Classes Uses Distinct Temporal and Activity-Related Programs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Genetic regulation of central synapse formation and organization in Drosophila melanogaster.Genetics · 2022Review
- A Quantitative Model of Sporadic Axonal Degeneration in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Astrocytes close a motor circuit critical period.Nature · 2021Article
- The Cytoplasmic LIM Domain Protein Espinas Contributes to Photoreceptor Layer Selection in the Visual System.Biology · 2020Article
- A pair of ascending neurons in the subesophageal zone mediates aversive sensory inputs-evoked backward locomotion in Drosophila larvae.PLoS genetics · 2020Article
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- The Conserved IgSF9 Protein Borderless Regulates Axonal Transport of Presynaptic Components and Color Vision inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.Developmental cell · 2019Article
- Identified Serotonergic Modulatory Neurons Have Heterogeneous Synaptic Connectivity within the Olfactory System ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior.Nature neuroscience · 2017Article
- Review
- Analyzing Synaptic Modulation of Drosophila melanogaster Photoreceptors after Exposure to Prolonged Light.Journal of visualized experiments : JoVE · 2017Article
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Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A hallmark of the central nervous system is its spatial and functional organization in synaptic layers. During neuronal development, axons form transient contacts with potential post-synaptic elements and establish synapses with appropriate partners at specific layers. These processes are regulated by synaptic cell-adhesion molecules. In the Drosophila visual system, R7 and R8 photoreceptor subtypes target distinct layers and form en passant pre-synaptic terminals at stereotypic loci of the axonal shaft. A leucine-rich repeat transmembrane protein, Capricious (Caps), is known to be selectively expressed in R8 axons and their recipient layer, which led to the attractive hypothesis that Caps mediates R8 synaptic specificity by homophilic adhesion. Contradicting this assumption, our results indicate that Caps does not have a prominent role in synaptic-layer targeting and synapse formation in Drosophila photoreceptors, and that the specific recognition of the R8 target layer does not involve Caps homophilic axon-target interactions. We generated flies that express a tagged synaptic marker to evaluate the presence and localization of synapses in R7 and R8 photoreceptors. These genetic tools were used to assess how the synaptic profile is affected when axons are forced to target abnormal layers by expressing axon guidance molecules. When R7 axons were mistargeted to the R8-recipient layer, R7s either maintained an R7-like synaptic profile or acquired a similar profile to r8s depending on the overexpressed protein. When R7 axons were redirected to a more superficial medulla layer, the number of presynaptic terminals was reduced. These results indicate that cell-surface molecules are able to dictate synapse loci by changing the axon terminal identity in a partially cell-autonomous manner, but that presynapse formation at specific sites also requires complex interactions between pre- and post-synaptic elements.
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