ArticlePloS one2013
Microdamage caused by fatigue loading in human cancellous bone: relationship to reductions in bone biomechanical performance.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Methods for bone quality assessment in human bone tissue: a systematic review.Journal of orthopaedic surgery and research · 2022Pooled it
- Effects of different numbers of micro-osteoperforations on acceleration of orthodontic tooth movement and alveolar bone remodeling in rats.BMC oral health · 2026Article
- Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice.Nature communications · 2026Article
- Does undersizing of the tibial component in unicompartmental knee arthroplasty increase the risk of fracture? A biomechanical study.Knee surgery & related research · 2025Article
- Advancement of bottom-up precipitation synthesis and applications of barium sulphate nanoparticles.RSC advances · 2025Review
- Four-tract probabilistic tractography technique for target selection in essential tremor treatment with magnetic resonance-guided focused ultrasound.European radiology · 2024Article
- Assessment of subchondral bone microdamage quantification using contrast-enhanced imaging techniques.Journal of anatomy · 2024Article
- Bone marrow lesions: plugging the holes in our knowledge using animal models.Nature reviews. Rheumatology · 2023Review
- Trabecular bone microcrack accumulation in patients treated with bisphosphonates for durations up to 16 years.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Distributions of Microdamage Are Altered Between Trabecular Rods and Plates in Cancellous Bone From Men With Type 2 Diabetes Mellitus.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Animal Models of Bone Marrow Lesions in Osteoarthritis.JBMR plus · 2022Review
- Sex, but not age and bone mass index positively impact on the development of osteochondral micro-defects and the accompanying cellular alterations during osteoarthritis progression.Chronic diseases and translational medicine · 2022Article
- Biomechanical and Microstructural Properties of Subchondral Bone From Three Metacarpophalangeal Joint Sites in Thoroughbred Racehorses.Frontiers in veterinary science · 2022Article
- Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues.Therapeutic advances in musculoskeletal disease · 2022Review
- Mechano-Regulation of Trabecular Bone Adaptation Is Controlled by the LocalFrontiers in bioengineering and biotechnology · 2020Article
- Bone-inspired microarchitectures achieve enhanced fatigue life.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Metacarpal trabecular bone varies with distinct hand-positions used in hominid locomotion.Journal of anatomy · 2019Article
- High-precision method for cyclic loading of small-animal vertebrae to assess bone quality.Bone reports · 2018Article
- Bone marrow lesions in osteoarthritis: What lies beneath.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Review
- Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Vertebral fractures associated with osteoporosis are often the result of tissue damage accumulated over time. Microscopic tissue damage (microdamage) generated in vivo is believed to be a mechanically relevant aspect of bone quality that may contribute to fracture risk. Although the presence of microdamage in bone tissue has been documented, the relationship between loading, microdamage accumulation and mechanical failure is not well understood. The aim of the current study was to determine how microdamage accumulates in human vertebral cancellous bone subjected to cyclic fatigue loading. Cancellous bone cores (n = 32) from the third lumbar vertebra of 16 donors (10 male, 6 female, age 76 ± 8.8, mean ± SD) were subjected to compressive cyclic loading at σ/E0 = 0.0035 (where σ is stress and E0 is the initial Young's modulus). Cyclic loading was suspended before failure at one of seven different amounts of loading and specimens were stained for microdamage using lead uranyl acetate. Damage volume fraction (DV/BV) varied from 0.8 ± 0.5% (no loading) to 3.4 ± 2.1% (fatigue-loaded to complete failure) and was linearly related to the reductions in Young's modulus caused by fatigue loading (r(2) = 0.60, p<0.01). The relationship between reductions in Young's modulus and proportion of fatigue life was nonlinear and suggests that most microdamage generation occurs late in fatigue loading, during the tertiary phase. Our results indicate that human vertebral cancellous bone tissue with a DV/BV of 1.5% is expected to have, on average, a Young's modulus 31% lower than the same tissue without microdamage and is able to withstand 92% fewer cycles before failure than the same tissue without microdamage. Hence, even small amounts of microscopic tissue damage in human vertebral cancellous bone may have large effects on subsequent biomechanical performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.