ArticlePloS one2013
Intra-specific regulatory variation in Drosophila pseudoobscura.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents.Cell proliferation · 2026Article
- Intraspecific gene regulation in cis- and trans.Evolution; international journal of organic evolution · 2025Review
- Transcriptional misexpression in hybrids between species linked by gene flow is associated with patterns of sequence divergence.Genome biology and evolution · 2023Article
- Molecular and evolutionary processes generating variation in gene expression.Nature reviews. Genetics · 2021Review
- Few Fixed Variants between Trophic Specialist Pupfish Species Reveal Candidate Cis-Regulatory Alleles Underlying Rapid Craniofacial Divergence.Molecular biology and evolution · 2021Article
- Contributions of cis- and trans-Regulatory Evolution to Transcriptomic Divergence across Populations in the Drosophila mojavensis Larval Brain.Genome biology and evolution · 2020Article
- CompensatoryEvolution letters · 2019Article
- Dominance and Sexual Dimorphism Pervade the Salix purpurea L. Transcriptome.Genome biology and evolution · 2017Article
- Article
- Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species.Genome biology and evolution · 2017Article
- The Interplay of Temperature and Genotype on Patterns of Alternative Splicing in Drosophila melanogaster.Genetics · 2016Article
- Gene Regulatory Evolution During Speciation in a Songbird.G3 (Bethesda, Md.) · 2016Article
- Identification of Lineage-Specific Cis-Regulatory Modules Associated with Variation in Transcription Factor Binding and Chromatin Activity Using Ornstein-Uhlenbeck Models.Molecular biology and evolution · 2015Article
- Hybrid male sterility and genome-wide misexpression of male reproductive proteases.Scientific reports · 2015Article
- Evolution of gene regulation during transcription and translation.Genome biology and evolution · 2015Article
- Negative feedback buffers effects of regulatory variants.Molecular systems biology · 2015Article
- Temperature stress mediates decanalization and dominance of gene expression in Drosophila melanogaster.PLoS genetics · 2015Article
- Sequencing pools of individuals - mining genome-wide polymorphism data without big funding.Nature reviews. Genetics · 2014Review
- Tempo and mode of regulatory evolution in Drosophila.Genome research · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
It is generally accepted that gene regulation serves an important role in determining the phenotype. To shed light on the evolutionary forces operating on gene regulation, previous studies mainly focused on the expression differences between species and their inter-specific hybrids. Here, we use RNA-Seq to study the intra-specific distribution of cis- and trans-regulatory variation in Drosophila pseudoobscura. Consistent with previous results, we find almost twice as many genes (26%) with significant trans-effects than genes with significant cis-effects (18%). While this result supports the previous suggestion of a larger mutational target of trans-effects, we also show that trans-effects may be subjected to purifying selection. Our results underline the importance of intra-specific analyses for the understanding of the evolution of gene expression.
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Registered trials
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