SynthesisPloS one2013
Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Menopausal hormone therapy and women's health: An umbrella review.PLoS medicine · 2021Pooled it
- Reproductive factors in relation to risk of brain tumors in women: an updated meta-analysis of 27 independent studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Overweight, obesity and meningioma risk: a meta-analysis.PloS one · 2014Pooled it
- The Relationship Between Hormone Replacement Therapy and Risk of Kidney Cancer in Women: A Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Risk of intracranial meningioma requiring surgical intervention among recent hormonal contraceptives users.Journal of neuro-oncology · 2026Article
- Comparative analysis of clinical outcomes cerebellopontine angle meningioma versus cerebellopontine angle schwannoma: A retrospective insight from Pakistan.Pakistan journal of medical sciences · 2025Article
- Oral contraceptives with progestogens desogestrel or levonorgestrel and risk of intracranial meningioma: national case-control study.BMJ (Clinical research ed.) · 2025Article
- Development of a Machine Learning Algorithm for the Prediction of WHO Grade 1 Meningioma Recurrence.Cureus · 2025Article
- A four-hit mechanism is sufficient for meningioma development.Journal of neuro-oncology · 2025Article
- MRI-based deep transfer learning models for predicting progesterone receptor expression in meningioma.Frontiers in oncology · 2025Article
- Association of thyroid disease and intracranial meningiomas: a retrospective analysis with external validation.Frontiers in oncology · 2025Article
- Recommendations on the management of meningioma and sex hormone therapy: The results of a collaborative effort between neurosurgical, endocrine and gynecological societies.Brain & spine · 2025Article
- Meningioma recurrence: Time for an online prediction tool?Surgical neurology international · 2024Review
- The causal relationship between genetically determined telomere length and meningiomas risk.Frontiers in neurology · 2023Article
- Brain Invasion and Trends in Molecular Research on Meningioma.Brain tumor research and treatment · 2023Review
- Intradural extramedullary spinal cord meningioma with a rare extradural foraminal extension: A case report.Frontiers in surgery · 2023Article
- Meningiomas in Gynecology and Reproduction: an Updated Overview for Clinical Practice.Reproductive sciences (Thousand Oaks, Calif.) · 2022Review
- Consensus core clinical data elements for meningiomas (v2021.1).Neuro-oncology · 2022Article
- Inflammatory Tumor Microenvironment in Cranial Meningiomas: Clinical Implications and Intraindividual Reproducibility.Diagnostics (Basel, Switzerland) · 2022Article
- Association of Hormonal Contraception with Meningioma Location in Indonesian Patients.Asian Pacific journal of cancer prevention : APJCP · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveA number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more precise estimates of risk.
methodsWe conducted a literature search using PubMed and EMBASE databases to July 2013, without any limitations. Random effects models were used to summarize results.
resultsTwelve case-control and six cohort studies were included in this meta-analysis. We found that an increased risk of meningioma was associated with HRT use(RR = 1.19, 95% CI = 1.01-1.40), postmenopausal women(RR = 1.32, 95% CI = 1.07-1.64) and parity(RR = 1.18, 95% CI = 1.00-1.40).No significant associations were observed for OC use (RR = 0.93, 95% CI = 0.83-1.03), age at menarche(RR = 1.06, 95% CI = 0.92-1.21), age at menopause(RR = 1.03, 95% CI = 0.81-1.30), or age at first birth(RR = 0.94, 95% CI = 0.80-1.10).
conclusionIn conclusion, the results of our study support the hypothesis that longer exposure to effect of female sex hormones may increase the risk of meningioma in women, yet additional studies are warranted to confirm our findings and identify the underlying biological mechanisms.
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