ArticlePloS one2013
Imaging of an inflammatory injury in the newborn rat brain with photoacoustic tomography.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Transcranial photoacoustic imaging of indocyanine green J-aggregates reveals cerebral signal changes in lipopolysaccharide-induced systemic inflammation.Photoacoustics · 2026Article
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Multispectral optoacoustic tomography (MSOT): Monitoring neurovascular changes in a mouse repetitive traumatic brain injury model.Journal of neuroscience methods · 2023Article
- Application of photoacoustic computed tomography in biomedical imaging: A literature review.Bioengineering & translational medicine · 2023Review
- Photoacoustic Imaging in Biomedicine and Life Sciences.Life (Basel, Switzerland) · 2022Review
- Photoacoustic imaging as a highly efficient and precise imaging strategy for the evaluation of brain diseases.Quantitative imaging in medicine and surgery · 2021Review
- Photostability of Contrast Agents for Photoacoustics: The Case of Gold Nanorods.Nanomaterials (Basel, Switzerland) · 2021Review
- Multimodal Contrast Agents for Optoacoustic Brain Imaging in Small Animals.Frontiers in bioengineering and biotechnology · 2021Review
- Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure.Journal of neuroinflammation · 2018Article
- A numerical analysis of a semi-dry coupling configuration in photoacoustic computed tomography for infant brain imaging.Photoacoustics · 2017Article
- Altered Functional Connectivity Following an Inflammatory White Matter Injury in the Newborn Rat: A High Spatial and Temporal Resolution Intrinsic Optical Imaging Study.Frontiers in neuroscience · 2017Article
- Brain Vascular Imaging Techniques.International journal of molecular sciences · 2016Review
- New means to assess neonatal inflammatory brain injury.Journal of neuroinflammation · 2015Review
- Photoacoustic imaging of cerebral hypoperfusion during acupuncture.Biomedical optics express · 2015Article
- Non-invasive parenchymal, vascular and metabolic high-frequency ultrasound and photoacoustic rat deep brain imaging.Journal of visualized experiments : JoVE · 2015Article
- Simultaneous photoacoustic and optically mediated ultrasound microscopy: an in vivo study.Biomedical optics express · 2015Article
- Photoacoustic Brain Imaging: from Microscopic to Macroscopic Scales.Neurophotonics · 2014Article
- Photoacoustic imaging of breast microcalcifications: a preliminary study with 8-gauge core-biopsied breast specimens.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe precise assessment of cerebral saturation changes during an inflammatory injury in the developing brain, such as seen in periventricular leukomalacia, is not well defined. This study investigated the impact of inflammation on locoregional cerebral oxygen saturation in a newborn rodent model using photoacoustic imaging.
methods1 mg/kg of lipopolysaccharide(LPS) diluted in saline or saline alone was injected under ultrasound guidance directly in the corpus callosum of P3 rat pups. Coronal photoacoustic images were carried out 24 h after LPS exposure. Locoregional oxygen saturation (SO2) and resting state connectivity were assessed in the cortex and the corpus callosum. Microvasculature was then evaluated on cryosection slices by lectin histochemistry.
resultsSignificant reduction of SO2 was found in the corpus callosum; reduced SO2 was also found in the cortex ipsilateral to the injection site. Seed-based functional connectivity analysis showed that bilateral connectivity was not affected by LPS exposure. Changes in locoregional oxygen saturation were accompanied by a significant reduction in the average length of microvessels in the left cortex but no differences were observed in the corpus callosum.
conclusionInflammation in the developing brain induces marked reduction of locoregional oxygen saturation, predominantly in the white matter not explained by microvascular degeneration. The ability to examine regional saturation offers a new way to monitor injury and understand physiological disturbance non-invasively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.