ArticlePloS one2013
The first salamander defensin antimicrobial peptide.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Novel antimicrobial peptides and peptide-microbiome crosstalk in Appalachian salamander skin.NPJ biofilms and microbiomes · 2025Article
- Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander (Pharmaceutics · 2024Article
- Circulating MiRNAs Are Associated With Low-grade Systemic Inflammation and Leptin Levels in Older Adults.Inflammation · 2023Article
- In Vitro Investigation of the Antibacterial Activity of Salamander Skin Peptides.Current microbiology · 2023Article
- Disease state associated with chronic toe lesions in hellbenders may alter anti-chytrid skin defenses.Scientific reports · 2023Article
- Ramosin: The First Antibacterial Peptide Identified onPharmaceutics · 2022Article
- Immunity in salamander regeneration: Where are we standing and where are we headed?Developmental dynamics : an official publication of the American Association of Anatomists · 2021Review
- Winter is coming-Temperature affects immune defenses and susceptibility to Batrachochytrium salamandrivorans.PLoS pathogens · 2021Article
- The Arsenal of Bioactive Molecules in the Skin Secretion of Urodele Amphibians.Frontiers in pharmacology · 2021Review
- The amphibian complement system and chytridiomycosis.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2020Review
- The Antioxidant Peptide Salamandrin-I: First Bioactive Peptide Identified from Skin Secretion of Salamandra Genus (Salamandra salamandra).Biomolecules · 2020Article
- A New Family of Diverse Skin Peptides from the Microhylid Frog GenusMolecules (Basel, Switzerland) · 2020Article
- Multi-tissue transcriptomes of caecilian amphibians highlight incomplete knowledge of vertebrate gene families.DNA research : an international journal for rapid publication of reports on genes and genomes · 2019Article
- Skin mucosome activity as an indicator of Batrachochytrium salamandrivorans susceptibility in salamanders.PloS one · 2018Article
- High-Throughput Identification of Antimicrobial Peptides from Amphibious Mudskippers.Marine drugs · 2017Article
- Skin microbiota differs drastically between co-occurring frogs and newts.Royal Society open science · 2017Article
- Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.Genome biology and evolution · 2016Article
- Amphibian chytridiomycosis: a review with focus on fungus-host interactions.Veterinary research · 2015Review
- Molecular Evolutionary Analysis of β-Defensin Peptides in Vertebrates.Evolutionary bioinformatics online · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides have been widely identified from amphibian skins except salamanders. A novel antimicrobial peptide (CFBD) was isolated and characterized from skin secretions of the salamander, Cynops fudingensis. The cDNA encoding CFBD precursor was cloned from the skin cDNA library of C. fudingensis. The precursor was composed of three domains: signal peptide of 17 residues, mature peptide of 41 residues and intervening propeptide of 3 residues. There are six cysteines in the sequence of mature CFBD peptide, which possibly form three disulfide-bridges. CFBD showed antimicrobial activities against Staphylococcus aureus, Bacillus subtilis, Candida albicans and Escherichia coli. This peptide could be classified into family of β-defensin based on its sequence similarity with β-defensins from other vertebrates. Evolution analysis indicated that CFBD was close to fish β-defensin. As far as we know, CFBD is the first β-defensin antimicrobial peptide from salamanders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.