Evidence map›Paper›PMID 24386080›Full record

ArticlePloS one2013

IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer.

Meng Xue, Yanfei Fang, Guoming Sun, Wei Zhuo, Jing Zhong, Cuijuan Qian, Lan Wang, Liangjing Wang, Jianmin Si, Shujie Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  6. Effects ofHuman reproduction open · 2024
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  13. RestoringFrontiers in oncology · 2021
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  19. Overexpression of IGFBP3 is associated with poor prognosis and tumor metastasis in nasopharyngeal carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Meng XueDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Yanfei FangDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Guoming SunInstitute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China ; Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Wei ZhuoInstitute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Jing ZhongInstitute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China ; Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Cuijuan QianDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Lan WangDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Liangjing WangInstitute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China ; Department of Gastroenterology, Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Jianmin SiDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Shujie ChenDepartment of Gastroenterology, Sir Runrun Shaw Hospital, Zhejiang University, Hangzhou, Zhejiang, China ; Institute of Gastroenterology, Zhejiang University, Hangzhou, Zhejiang, China.
Zhejiang University · CNSir Run Run Shaw Hospital · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homeobox D10 (HoxD10) plays important roles in the differentiation of embryonic cells and progression of breast cancer. Our previous report revealed that insulin-like growth factor binding protein-3 (IGFBP3) was regulated by HoxD10 in gastric cancer cells; however, the functional roles and underlying mechanisms of IGFBP3 in gastric cancer remain unclear. Here, we found that the expression of IGFBP3 were upregulated after ectopic expression of HoxD10 in gastric cancer cells. Chromatin immunoprecipitation assay showed that HoxD10 bound to three potential regions of IGFBP3 promoter. Exogenous HoxD10 significantly enhanced the activity of luciferase reporter containing these binding regions in gastric cancer cells. Further data showed that all of these binding sites had Hox binding element "TTAT". Immunohistochemical staining results revealed that IGFBP3 expression was significantly downregulated in 86 gastric adenocarcinomas tissues relative to their adjacent non-cancerous tissues (p<0.001). Moreover, IGFBP3 expression was significantly lower in gastric tumor with lymph node metastasis compared with that without lymph node metastasis (p=0.045). Patients with high expression level of IGFBP3 showed favorable 5 year overall survival (p=0.011). Knockdown of IGFBP3 accelerated gastric cancer cell migration and invasion and induced the expression of invasive factors including MMP14, uPA and uPAR. Thus, our data suggest that HoxD10-targeted gene IGFBP3 may suppress gastric cancer cell invasion and favors the survival of gastric cancer patients.

Indexed as

Cell Line, TumorCell MovementGene Expression Regulation, NeoplasticGene Knockdown TechniquesHomeodomain ProteinsHumansImmunohistochemistryInsulin-Like Growth Factor Binding Protein 3Matrix Metalloproteinase 14Neoplasm InvasivenessPrognosisPromoter Regions, GeneticReceptors, Urokinase Plasminogen ActivatorStomach NeoplasmsSurvival AnalysisTranscription FactorsHomeodomain ProteinsHOXD10 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Matrix Metalloproteinase 14MMP14 protein, humanReceptors, Urokinase Plasminogen ActivatorTranscription FactorsUrokinase-Type Plasminogen Activator

Identifiers

PMID24386080
PMCPMC3873913
OpenAlexW2002376660

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.