ArticleStem cells international2013
Coculture with Late, but Not Early, Human Endothelial Progenitor Cells Up Regulates IL-1 β Expression in THP-1 Monocytic Cells in a Paracrine Manner.
Article in Stem cells international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Exploring Endothelial Colony-Forming Cells to Better Understand the Pathophysiology of Disease: An Updated Review.Stem cells international · 2022Review
- Differences in senescence of late Endothelial Progenitor Cells in non-smokers and smokers.Tobacco induced diseases · 2021Article
- Platelets of Healthy Origins Promote Functional Improvement of Atherosclerotic Endothelial Progenitor Cells.Frontiers in pharmacology · 2019Article
- Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels.Journal of biomedical materials research. Part A · 2017Article
- Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-Benzopyrene/Angiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm.Stem cells international · 2017Article
- Delayed Endothelial Progenitor Cell Therapy Promotes Bone Defect Repair in a Clinically Relevant Rat Model.Stem cells international · 2017Article
- Exercise induces stromal cell-derived factor-1α-mediated release of endothelial progenitor cells with increased vasculogenic function.Plastic and reconstructive surgery · 2015Article
- Endothelial progenitor cells in tumor angiogenesis: another brick in the wall.Stem cells international · 2015Review
- Circulating angiogenic cell dysfunction in patients with hereditary hemorrhagic telangiectasia.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelial progenitor cells (EPCs) have been used in clinical trials to treat ischemic heart disease. Monocyte infiltration plays an important role in inflammation, angiogenesis, and tissue repair during tissue ischemia. It is important to understand the interactions between EPCs and monocytes. In this study, a human EPC/THP-1 monocytic cell coculture system was used to examine EPC effect on IL-1 α , IL-1 β , and TNF- α expression in THP-1 cells. Late, but not early, EPCs upregulated IL-1 β expression at both mRNA and protein levels. In contrast, neither early nor late EPCs affected IL-1 α or TNF- α expression. Coculture with human umbilical vein endothelial cells did not alter IL-1 β expression. It has been shown that activation of integrin β 2 in human neutrophils augments IL-1 β synthesis; however integrin β 2 was not involved in IL-1 β expression in THP-1 cells. Addition of late EPC conditioned medium to THP-1 cell culture led to a modest increase of IL-1 β mRNA levels, indicating that late EPCs upregulate IL-1 β expression partly through a paracrine pathway. IL-1 β , an important inflammation mediator, has been shown to promote EPC function. Our data therefore suggest that late EPCs can exert self-enhancement effects by interacting with monocytes and that EPCs might modulate inflammatory reactions by regulating IL-1 β expression in monocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.