ReviewFrontiers in immunology2013
A replicative self-renewal model for long-lived plasma cells: questioning irreversible cell cycle exit.
Review in Frontiers in immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Circulating plasma cells: from basic mechanisms to clinical applications.Frontiers in immunology · 2025Review
- Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states.Nature immunology · 2024Article
- Review
- Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).European journal of immunology · 2021Review
- Review
- Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation.Blood · 2018Article
- Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event.Frontiers in oncology · 2018Article
- Plasma cell survival in the absence of B cell memory.Nature communications · 2017Article
- Evolutionary biology of high-risk multiple myeloma.Nature reviews. Cancer · 2017Review
- Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire.Nature communications · 2016Observational
- The myeloma stem cell concept, revisited: from phenomenology to operational terms.Haematologica · 2016Review
- Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.Immunity · 2016Article
- Article
- Transcription factors regulating B cell fate in the germinal centre.Clinical and experimental immunology · 2016Review
- Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells.Oncotarget · 2015Article
- Whole-genome fingerprint of the DNA methylome during human B cell differentiation.Nature genetics · 2015Article
- LKB1 regulates germinal center formation and termination.Cell cycle (Georgetown, Tex.) · 2015Article
- The origin of the plasma-cell heterogeneity.Frontiers in immunology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Plasma cells are heterogenous in terms of their origins, secretory products, and lifespan. A current paradigm is that cell cycle exit in plasma cell differentiation is irreversible, following a pattern familiar in short-lived effector populations in other hemopoietic lineages. This paradigm no doubt holds true for many plasma cells whose lifespan can be measured in days following the completion of differentiation. Whether this holds true for long-lived bone marrow plasma cells that are potentially maintained for the lifespan of the organism is less apparent. Added to this the mechanisms that establish and maintain cell cycle quiescence in plasma cells are incompletely defined. Gene expression profiling indicates that in the transition of human plasmablasts to long-lived plasma cells a range of cell cycle regulators are induced in a pattern that suggests a quiescence program with potential for cell cycle re-entry. Here a model of relative quiescence with the potential for replicative self-renewal amongst long-lived plasma cells is explored. The implications of such a mechanism would be diverse, and the argument is made here that current evidence is not sufficiently strong that the possibility should be disregarded.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.