ArticlePLoS genetics2013
Insulin/IGF-regulated size scaling of neuroendocrine cells expressing the bHLH transcription factor Dimmed in Drosophila.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Feeding decision-making by a single neuron via disparate neurotransmitters.Nature communications · 2026Article
- Article
- Article
- Leucokinin and Associated Neuropeptides Regulate Multiple Aspects of Physiology and Behavior inInternational journal of molecular sciences · 2021Review
- Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae.PLoS genetics · 2020Article
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- Genetic Underpinnings of Host Manipulation byG3 (Bethesda, Md.) · 2020Article
- ER-Ca2+ sensor STIM regulates neuropeptides required for development under nutrient restriction in Drosophila.PloS one · 2019Article
- Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin.PLoS genetics · 2018Article
- Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila.Cellular and molecular life sciences : CMLS · 2018Article
- A Complex Relationship between Immunity and Metabolism in Drosophila Diet-Induced Insulin Resistance.Molecular and cellular biology · 2018Article
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
- Reduced insulin signaling maintains electrical transmission in a neural circuit in aging flies.PLoS biology · 2017Article
- IPDevelopment (Cambridge, England) · 2017Article
- Transcriptional Reorganization ofFrontiers in molecular neuroscience · 2017Article
- Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancy.Scientific reports · 2016Article
- TheFrontiers in molecular neuroscience · 2016Article
- Genome-wide features of neuroendocrine regulation in Drosophila by the basic helix-loop-helix transcription factor DIMMED.Nucleic acids research · 2015Article
- Peptidergic cell-specific synaptotagmins in Drosophila: localization to dense-core granules and regulation by the bHLH protein DIMMED.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons and other cells display a large variation in size in an organism. Thus, a fundamental question is how growth of individual cells and their organelles is regulated. Is size scaling of individual neurons regulated post-mitotically, independent of growth of the entire CNS? Although the role of insulin/IGF-signaling (IIS) in growth of tissues and whole organisms is well established, it is not known whether it regulates the size of individual neurons. We therefore studied the role of IIS in the size scaling of neurons in the Drosophila CNS. By targeted genetic manipulations of insulin receptor (dInR) expression in a variety of neuron types we demonstrate that the cell size is affected only in neuroendocrine cells specified by the bHLH transcription factor DIMMED (DIMM). Several populations of DIMM-positive neurons tested displayed enlarged cell bodies after overexpression of the dInR, as well as PI3 kinase and Akt1 (protein kinase B), whereas DIMM-negative neurons did not respond to dInR manipulations. Knockdown of these components produce the opposite phenotype. Increased growth can also be induced by targeted overexpression of nutrient-dependent TOR (target of rapamycin) signaling components, such as Rheb (small GTPase), TOR and S6K (S6 kinase). After Dimm-knockdown in neuroendocrine cells manipulations of dInR expression have significantly less effects on cell size. We also show that dInR expression in neuroendocrine cells can be altered by up or down-regulation of Dimm. This novel dInR-regulated size scaling is seen during postembryonic development, continues in the aging adult and is diet dependent. The increase in cell size includes cell body, axon terminations, nucleus and Golgi apparatus. We suggest that the dInR-mediated scaling of neuroendocrine cells is part of a plasticity that adapts the secretory capacity to changing physiological conditions and nutrient-dependent organismal growth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.