ArticleGenetics and molecular biology2013
The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells.
Article in Genetics and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 34 citations in OpenAlex.
- Biological, genetic, neurological and environmental influences on homosexuality-a narrative review.Frontiers in behavioral neuroscience · 2025Review
- Global DNA Methylation Levels Viz-a-Viz Genetic and Biochemical Variations in One Carbon Metabolic Pathway: An Exploratory Study from North India.Biochemical genetics · 2024Article
- Review
- Lack of Association ofGenetics research · 2023Article
- Homocysteine metabolism as the target for predictive medical approach, disease prevention, prognosis, and treatments tailored to the person.The EPMA journal · 2021Review
- Fatigue in Women with Fibromyalgia: A Gene-Physical Activity Interaction Study.Journal of clinical medicine · 2021Article
- Methylenetetrahydrofolate reductase gene polymorphism, global DNA methylation and blood pressure: a population based study from North India.BMC medical genomics · 2021Article
- Association Study ofFrontiers in psychiatry · 2021Article
- Methylenetetrahydrofolate reductase and psychiatric diseases.Translational psychiatry · 2018Review
- No evidence for association ofClinical epigenetics · 2018Article
- Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer.International journal of molecular sciences · 2017Article
- Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.Epigenetics · 2015Article
- Global and gene-specific DNA methylation and hydroxymethylation in human skin exposed and not exposed to sun radiation.Anais brasileiros de dermatologiaArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is mediated by DNA methyltransferases (DNMTs) that add a methyl group to the 5'-carbon of cytosine. The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle involving the methyl donor S-adenosyl-L-methionine (SAM). The MTHFR C677T polymorphism results in a thermolabile enzyme with reduced activity that is predicted to influence the DNA methylation status. In this study, we investigated the impact of the MTHFR C677T polymorphism on the global DNA methylation of oral epithelial cells obtained from 54 healthy subjects. There were no significant differences in global DNA methylation among the MTHFR CC, CT and TT genotypes (p = 0.75; Kruskal-Wallis test).
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