ArticleTurkish journal of haematology : official journal of Turkish Society of Haematology2013
High Throughput FISH Analysis: A New, Sensitive Option For Evaluation of Hematological Malignancies.
Article in Turkish journal of haematology : official journal of Turkish Society of Haematology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach. MATERIALS AND
methodsWe performed a HTFA study of bone marrow aspiration and peripheral blood samples of 77 cases (n=19 myelodysplastic syndrome, n=17 acute lymphoblastic leukemia, n=9 chronic myeloid leukemia, n=32 acute myeloid leukemia) with hematological malignancies during the periods of initial diagnosis, treatment, and/or follow-up.
resultsBoth numerical and structural abnormalities were detected by HTFA. We observed aberrations in 88% of our acute lymphoblastic leukemia patients, 25% of acute myeloid leukemia patients, and 31% of myelodysplastic syndrome patients. In chronic myeloid leukemia cases, aberration was not detected by HTFA.
conclusionOur results showed that HTFA, combined with other methods, will gradually take a place in the routine diagnosis of hematologic malignancies. CONFLICT OF INTEREST: None declared.
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