Evidence map›Paper›PMID 24385670›Full record

ArticleTransactions of the American Ophthalmological Society2013

Postulating a role for connective tissue elements in inferior oblique muscle overaction (an American Ophthalmological Society thesis).

David Stager, Linda K McLoon, Joost Felius

Open access · greenAbstract readComparative Study
PubMed Full text at PMC
In one paragraph

Article in Transactions of the American Ophthalmological Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 25 citations in OpenAlex.

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  5. Comitant strabismus etiology: extraocular muscle integrity and central nervous system involvement-a narrative review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Review
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  19. Abnormal activity of neurons in abducens nucleus of strabismic monkeys.Investigative ophthalmology & visual science · 2014
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David StagerDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, and Pediatric Ophthalmology & Adult Strabismus, PA, Plano, Texas (Dr Stager); Departments of Ophthalmology and Visual Neurosciences, and Department of Neuroscience, University of Minnesota, Minneapolis (Dr McLoon); and the Retina Foundation of the Southwest, Dallas, Texas, and Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas (Dr Felius).
Linda K McLoonDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, and Pediatric Ophthalmology & Adult Strabismus, PA, Plano, Texas (Dr Stager); Departments of Ophthalmology and Visual Neurosciences, and Department of Neuroscience, University of Minnesota, Minneapolis (Dr McLoon); and the Retina Foundation of the Southwest, Dallas, Texas, and Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas (Dr Felius).
Joost FeliusDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, and Pediatric Ophthalmology & Adult Strabismus, PA, Plano, Texas (Dr Stager); Departments of Ophthalmology and Visual Neurosciences, and Department of Neuroscience, University of Minnesota, Minneapolis (Dr McLoon); and the Retina Foundation of the Southwest, Dallas, Texas, and Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas (Dr Felius).
Retina Foundation of the Southwest · US

Funding

Visual TestingP30EY011374 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI NEWMAN, ERIC A · 1996 to 2019
$8.8M
Novel Immunotoxin and IGF Therapy for StrabismusR01EY015313 · NEI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCLOON, LINDA K., MUSTARI, MICHAEL J · 2004 to 2022
$7.6M
NEI NIH HHS EY015313NEI NIH HHS P30 EY011374NEI NIH HHS R01 EY015313
6 · The paper itself

Abstract

purposeTo compare the localization and density of collagens I, IV, VI, and elastin, the major protein components of connective tissue, in the inferior oblique muscle of patients with overelevation in adduction and in controls and to characterize changes that develop following surgery. Biomechanical studies suggest that the connective tissue matrix plays a critical role in extraocular muscle function, determining tensile strength and force transmission during contraction.

methodsProspective laboratory-based case-control study of inferior oblique muscle specimens from 31 subjects: 16 with primary inferior oblique overaction, 6 with craniofacial dysostosis, and 9 normal controls. Collagen I, IV, VI, and elastin were localized and quantified using immunohistochemical staining. Densities were compared using analysis of variance and post hoc comparisons.

resultsIn primary inferior oblique overaction, all connective tissue components in unoperated specimens were elevated compared to controls (P<.0001). Previously operated muscles showed normal levels of collagens IV and VI (P>.27) but increased collagen I. In unoperated craniofacial dysostosis specimens, only elastin was elevated (P=.03), whereas density of collagens IV and VI was lower in previously operated vs unoperated specimens (P=.015).

conclusionsElevated collagen and elastin levels in the cohort with primary inferior oblique overaction are consistent with the clinical finding of muscle stiffness. Contrarily, normal connective tissue densities in craniofacial dysostosis support the hypothesis that overelevation in this group reflects anomalous muscle vectors rather than tissue changes. Surgical intervention was associated with changes in the connective tissue matrix in both cohorts. These results have ramifications for treating patients with overelevation in adduction.

Indexed as

AdultAgedChildChild, PreschoolCollagen Type ICollagen Type IVCollagen Type VIConnective TissueElastinExtracellular Matrix ProteinsFemaleHumansImmunoenzyme TechniquesInfantMaleMiddle AgedCollagen Type ICollagen Type IVCollagen Type VIElastinExtracellular Matrix Proteins

Identifiers

PMID24385670
PMCPMC3812716
OpenAlexW2135965746

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.