ArticleBlood2014
Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow.
Article in Blood, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanisms of actin-binding proteins in glycolysis-cytoskeleton coupling.Journal of translational medicine · 2026Review
- Challenge Specific Modulation of Responses to Adjuvant-Induced Innate Immune Memory.Immunology · 2026Article
- Profilin and Its Isoforms: Unravelling the Functional Diversity Across Life Forms.Current protein & peptide science · 2026Review
- Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes.Nature cardiovascular research · 2025Article
- Transcription factor Nkx2-3 maintains the self-renewal of hematopoietic stem cells by regulating mitophagy.Leukemia · 2023Article
- Review
- Mitochondria-actin cytoskeleton crosstalk in cell migration.Journal of cellular physiology · 2022Review
- Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization.Leukemia · 2022Article
- Development of a novel and synthetic HematoMiR technology that broadly modulates quiescence of stem cells and enhances HSC expansion.Cellular and molecular life sciences : CMLS · 2021Article
- Profilin 1 and Mitochondria-Partners in the Pathogenesis of Coronary Artery Disease?International journal of molecular sciences · 2021Review
- Article
- Development of Small Molecule MEIS Inhibitors that modulate HSC activity.Scientific reports · 2020Article
- Hematopoietic stem cell metabolism and stemness.Blood science (Baltimore, Md.) · 2019Review
- Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution.RNA biology · 2019Article
- Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions.Development (Cambridge, England) · 2019Article
- Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9.EBioMedicine · 2019Article
- TarGo: network based target gene selection system for human disease related mouse models.Laboratory animal research · 2019Article
- Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function.Annals of laboratory medicine · 2018Review
- CCCTC-binding factor is essential to the maintenance and quiescence of hematopoietic stem cells in mice.Experimental & molecular medicine · 2017Article
- Mitochondria and FOXO3 in stem cell homeostasis, a window into hematopoietic stem cell fate determination.Journal of bioenergetics and biomembranes · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
How stem cells interact with the microenvironment to regulate their cell fates and metabolism is largely unknown. Here we demonstrated that the deletion of the cytoskeleton-modulating protein profilin 1 (pfn1) in hematopoietic stem cell (HSCs) led to bone marrow failure, loss of quiescence, and mobilization and apoptosis of HSCs in vivo. A switch from glycolysis to mitochondrial respiration with increased reactive oxygen species (ROS) level was also observed in HSCs on pfn1 deletion. Importantly, treatment of pfn1-deficient mice with the antioxidant N-acetyl-l-cysteine reversed the ROS level and loss of quiescence of HSCs, suggesting that the metabolism is mechanistically linked to the cell cycle quiescence of stem cells. The actin-binding and proline-binding activities of pfn1 are required for its function in HSCs. Our study provided evidence that pfn1 at least partially acts through the axis of pfn1/Gα13/EGR1 to regulate stem cell retention and metabolism in the bone marrow.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.