ArticleThe Journal of cell biology2013
Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed.
- Investigation of serum proteome homeostasis during radiation therapy by a quantitative proteomics approach.Bioscience reports · 2019Trial
- STED/AFM as a tool to investigate mechanical and adhesive properties of migrating keratinocytes.Cell adhesion & migration · 2026Article
- Different Retinoid Micellar Formulations on Wound Healing: Efficacy and Collagen Structure.Pharmaceutics · 2026Article
- Amphibian-derived peptides as novel therapeutics for skin wound healing: Mechanisms, applications, and challenges.Zoological research · 2026Review
- Wild-Type Scandinavian Planarian-Derived Extracellular Vesicles Accelerate Skin Wound Healing in Burn and Mechanical Injuries.ACS omega · 2026Article
- Innovative Strategies: Use of Stromal Cell-Derived Secretome for Chronic Wound Therapy.International journal of molecular sciences · 2025Review
- The effect of the foreign body response on drug elution from subdermal delivery systems.Biomaterials · 2025Article
- Subcellular Cavitation Bubbles Induce Cellular Mechanolysis and Collective Wound Healing in Ultrasound-Inflicted Cell Ablation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity.PloS one · 2025Article
- Targeted Antibacterial Endolysin to Treat Infected Wounds on 3D Full-Thickness Skin Model: XZ.700 Efficacy.Pharmaceutics · 2024Article
- Review
- Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3DBiophysics reviews · 2024Review
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- Celastrol alleviates diabetic vascular injury via Keap1/Nrf2-mediated anti-inflammation.Frontiers in pharmacology · 2024Article
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- Mesenchymal Stem Cell Extracellular Vesicles from Tissue-Mimetic System Enhance Epidermal Regeneration via Formation of Migratory Cell Sheets.Tissue engineering and regenerative medicine · 2023Article
- Analysis of the potential of human cultured nasal epithelial cell sheets to differentiate into airway epithelium.FASEB bioAdvances · 2023Article
- A proof-of-concept study of the removal of early and late phase biofilm from skin wound models using a liquid acoustic stream.International wound journal · 2022Article
- Utilization of ex vivo tissue model to study skin regeneration following microneedle stimuli.Scientific reports · 2022Article
- Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wound healing is a complex process in which a tissue's individual cells have to be orchestrated in an efficient and robust way. We integrated multiplex protein analysis, immunohistochemical analysis, and whole-slide imaging into a novel medium-throughput platform for quantitatively capturing proliferation, differentiation, and migration in large numbers of organotypic skin cultures comprising epidermis and dermis. Using fluorescent time-lag staining, we were able to infer source and final destination of keratinocytes in the healing epidermis. This resulted in a novel extending shield reepithelialization mechanism, which we confirmed by computational multicellular modeling and perturbation of tongue extension. This work provides a consistent experimental and theoretical model for epidermal wound closure in 3D, negating the previously proposed concepts of epidermal tongue extension and highlighting the so far underestimated role of the surrounding tissue. Based on our findings, epidermal wound closure is a process in which cell behavior is orchestrated by a higher level of tissue control that 2D monolayer assays are not able to capture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.