ArticleThe Journal of cell biology2013
Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 35 citations in OpenAlex.
- Regulation of Hippo signaling by Atrophin in the developing Drosophila wing.Development (Cambridge, England) · 2026Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.Developmental biology · 2023Article
- The BAF chromatin complex component SMARCC1 does not mediate GLI transcriptional repression of Hedgehog target genes in limb buds.bioRxiv : the preprint server for biology · 2023Article
- Zebrafish model of RERE syndrome recapitulates key ophthalmic defects that are rescued by small molecule inhibitor of shh signaling.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Timing is everything: Transcriptional repression is not the default mode for regulating Hedgehog signaling.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022Article
- GLI transcriptional repression is inert prior to Hedgehog pathway activation.Nature communications · 2022Article
- Dissection of the microRNA Network Regulating Hedgehog Signaling inFrontiers in cell and developmental biology · 2022Article
- Gli Phosphorylation Code in Hedgehog Signal Transduction.Frontiers in cell and developmental biology · 2022Review
- Functional and transcriptomic analyses of the NF-Y family provide insights into the defense mechanisms of honeybees under adverse circumstances.Cellular and molecular life sciences : CMLS · 2020Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- HDAC1 inhibition ameliorates TDP-43-induced cell death in vitro and in vivo.Cell death & disease · 2020Article
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- A morphological novelty evolved by co-option of a reduced gene regulatory network and gene recruitment in a beetle.Proceedings. Biological sciences · 2018Article
- Identification of a melatonin receptor type 1A gene (AccMTNR1A) in Apis cerana cerana and its possible involvement in the response to low temperature stress.Die Naturwissenschaften · 2018Article
- The histone deacetylase HDAC1 positively regulates Notch signaling duringBiology open · 2018Article
- Machine Learning Analysis IdentifiesG3 (Bethesda, Md.) · 2017Article
- UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing.EMBO reports · 2017Article
- A mutant O-GlcNAcase enriches Drosophila developmental regulators.Nature chemical biology · 2017Article
- Atrophin controls developmental signaling pathways via interactions with Trithorax-like.eLife · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionarily conserved Hedgehog (Hh) signaling pathway is transduced by the Cubitus interruptus (Ci)/Gli family of transcription factors that exist in two distinct repressor (Ci(R)/Gli(R)) and activator (Ci(A)/Gli(A)) forms. Aberrant activation of Hh signaling is associated with various human cancers, but the mechanism through which Ci(R)/Gli(R) properly represses target gene expression is poorly understood. Here, we used Drosophila melanogaster and zebrafish models to define a repressor function of Atrophin (Atro) in Hh signaling. Atro directly bound to Ci through its C terminus. The N terminus of Atro interacted with a histone deacetylase, Rpd3, to recruit it to a Ci-binding site at the decapentaplegic (dpp) locus and reduce dpp transcription through histone acetylation regulation. The repressor function of Atro in Hh signaling was dependent on Ci. Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.