ArticleJournal of the American Heart Association2014
Association between ideal cardiovascular health and carotid intima-media thickness: a twin study.
Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- Poor cardiovascular health is associated with subclinical atherosclerosis in apparently healthy sub-Saharan African populations: an H3Africa AWI-Gen study.BMC medicine · 2021Pooled it
- Associations Between Health-Related Social Needs and Cardiovascular Health Among US Adults.Journal of the American Heart Association · 2024Article
- Association Between Cardiovascular Health and Subclinical Atherosclerosis Among Young Adults Using the American Heart Association's "Life's Essential 8" Metrics.Journal of the American Heart Association · 2024Article
- Ideal Cardiovascular Health Index and Its Determinants in a Rural South African Population.Global heart · 2020Article
- Nondietary Cardiovascular Health Metrics With Patient Experience and Loss of Productivity Among US Adults Without Cardiovascular Disease: The Medical Expenditure Panel Survey 2006 to 2015.Journal of the American Heart Association · 2020Article
- Early Pregnancy Cardiovascular Health and Subclinical Atherosclerosis.Journal of the American Heart Association · 2019Article
- Prevalence and Cardiovascular Health Impact of Family History of Premature Heart Disease in the United States: Analysis of the National Health and Nutrition Examination Survey, 2007-2014.Journal of the American Heart Association · 2019Article
- Association between cardiovascular health metrics and depression among U.S. adults: National Health and Nutrition Examination Survey, 2007-2014.Annals of epidemiology · 2019Article
- Association Between Cardiovascular Health and Cognitive Performance: A Twins Study.Journal of Alzheimer's disease : JAD · 2019Article
- Body Mass Index is Strongly Associated with Hypertension: Results from the Longevity Check-up 7+ Study.Nutrients · 2018Article
- Association between ideal cardiovascular health and markers of subclinical cardiovascular disease.Clinical cardiology · 2018Article
- Relationship of ideal cardiovascular health metrics with retinal vessel calibers and retinal nerve fiber layer thickness: a cross-sectional study.BMC cardiovascular disorders · 2018Article
- Association of Cardiovascular Health with Epicardial Adipose Tissue and Intima Media Thickness: The Kardiovize Study.Journal of clinical medicine · 2018Article
- Less Than Ideal Cardiovascular Health Is Associated With Shorter Leukocyte Telomere Length: The National Health and Nutrition Examination Surveys, 1999-2002.Journal of the American Heart Association · 2017Article
- Leukocyte telomere length and ideal cardiovascular health in American Indians: the Strong Heart Family Study.European journal of epidemiology · 2017Article
- The Association of Ideal Cardiovascular Health and Atherogenic Index of Plasma in Rural Population: A Cross-Sectional Study from Northeast China.International journal of environmental research and public health · 2016Article
- Changes in Cardiovascular Health Status and the Risk of New-Onset Hypertension in Kailuan Cohort Study.PloS one · 2016Article
- Cognitive Avoidant Coping Is Associated with Higher Carotid Intima Media Thickness Among Middle-Aged Adults.International journal of behavioral medicine · 2015Article
- Carotid atherosclerosis and cardiovascular health metrics in old subjects from the AGES-Reykjavik study.Atherosclerosis · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe American Heart Association (AHA) recently developed the Cardiovascular Health Index (CVHI), a health metric consisting of 7 modifiable risk factors. The relationship of the CVHI with preclinical markers, such as carotid intima-media thickness (CIMT) has not been assessed.
methodsWe examined 490 male monozygotic and dizygotic twins without overt cardiovascular disease. CIMT was measured using B-mode ultrasonography. Each of the 7 CVHI components (blood pressure, fasting glucose, total cholesterol, body mass index, physical activity, healthy diet, and smoking) was given a point score of 0, 1, or 2 to represent poor, intermediate, or ideal health, respectively. A CVHI summation score was computed (range 0 to 14) and categorized as inadequate (0 to 4), average (5 to 9), or optimum (10 to 14) cardiovascular health. Mixed-model regression was used to examine the association of the CVHI with CIMT.
resultsThe mean age of the twins was 55.4 years, and 61% were monozygotic. The mean CIMT was 0.75 (± 0.11) mm and the mean CVHI score was 7.7 (± 2.1). There was an inverse correlation between CVHI and CIMT (Spearman r=-0.22, P<0.01). For every 5-unit increase in overall CVHI score (indicating better cardiovascular health category), CIMT decreased by 0.045 mm (P<0.001) after adjusting for demographic variables and other confounders. Within monozygotic twin pairs, a 5-unit increment in CVHI score was associated with a 0.05 mm lower CIMT (P<0.001).
conclusionsThe CVHI is independently associated with CIMT and the association is not confounded by shared genetic and other familial factors.
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