ArticleJournal of the American Society for Mass Spectrometry2014
Structural documentation of glycan epitopes: sequential mass spectrometry and spectral matching.
Article in Journal of the American Society for Mass Spectrometry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Gas-Phase Structures of Fucosylated Oligosaccharides: Alkali Metal and Halogen Influences.The journal of physical chemistry. B · 2024Article
- Characterization of the human platelet N- and O-glycome upon storage using tandem mass spectrometry.Blood advances · 2023Article
- Mass Spectrometry-Based Techniques to Elucidate the Sugar Code.Chemical reviews · 2022Review
- Glycomics-informed glycoproteomic analysis of site-specific glycosylation for SARS-CoV-2 spike protein.STAR protocols · 2020Article
- Insights into Bioinformatic Applications for Glycosylation: Instigating an Awakening towards Applying Glycoinformatic Resources for Cancer Diagnosis and Therapy.International journal of molecular sciences · 2020Review
- Glycomics and glycoproteomics of viruses: Mass spectrometry applications and insights toward structure-function relationships.Mass spectrometry reviews · 2020Review
- Towards a standardized bioinformatics infrastructure for N- and O-glycomics.Nature communications · 2019Review
- Sequence Ion Structures and Dissociation Chemistry of Deprotonated Sucrose Anions.Journal of the American Society for Mass Spectrometry · 2018Article
- Structures of N-Glycans ofMolecular & cellular proteomics : MCP · 2018Article
- Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells.The Journal of biological chemistry · 2018Article
- Xylose Migration During Tandem Mass Spectrometry of N-Linked Glycans.Journal of the American Society for Mass Spectrometry · 2017Article
- Vibrational Signatures of Isomeric Lithiated N-acetyl-D-hexosamines by Gas-Phase Infrared Multiple-Photon Dissociation (IRMPD) Spectroscopy.Journal of the American Society for Mass Spectrometry · 2017Article
- Recent Advances in the Analysis of Complex Glycoproteins.Analytical chemistry · 2017Review
- Site-specific analysis of changes in the glycosylation of proteins in liver cirrhosis using data-independent workflow with soft fragmentation.Analytical and bioanalytical chemistry · 2017Article
- Circulating blood and platelets supply glycosyltransferases that enable extrinsic extracellular glycosylation.Glycobiology · 2017Article
- Computational approaches to define a human milk metaglycome.Bioinformatics (Oxford, England) · 2016Article
- The structures of glycophorin C N-glycans, a putative component of the GPC receptor site for Plasmodium falciparum EBA-140 ligand.Glycobiology · 2015Article
- Linkage and anomeric differentiation in trisaccharides by sequential fragmentation and variable-wavelength infrared photodissociation.Journal of the American Society for Mass Spectrometry · 2015Article
- The glycosylation-dependent interaction of perlecan core protein with LDL: implications for atherosclerosis.Journal of lipid research · 2015Article
- Targeted methods for quantitative analysis of protein glycosylation.Proteomics. Clinical applications · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Documenting mass spectral data is a fundamental aspect of accepted protocols. In this report, we contrast MS(n) sequential disassembly spectra obtained from natural and synthetic glycan epitopes. The epitopes considered are clusters found on conjugate termini of lipids and N- and O-glycans of proteins. The latter are most frequently pendant through a CID-labile HexNAc glycosidic linkage. The synthetic samples were supplied by collaborating colleagues and commercial sources and usually possessed a readily released reducing-end linker, a by-product of synthesis. All samples were comparably methylated, extracted, and MS(n) disassembled to compare their linkage and branching spectral details. Both sample types provide B-ion type fragments early in a disassembly pathway and their compositions are a suggestion of structure. Further steps of disassembly are necessary to confirm the details of linkage and branching. Included in this study were various Lewis and H antigens, 3- and 6-linked sialyl-lactosamine, NeuAc-2,8-NeuAc dimer, and Galα1,3Gal. Sample infusion provided high quality spectral data whereas disassembly to small fragments generates reproducible high signal/noise spectra for spectral matching. All samples were analyzed as sodium adducted positive ions. This study includes comparability statistics and evaluations on several mass spectrometers.
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