ReviewClinical reviews in allergy & immunology2014
Cogan's syndrome--clinical guidelines and novel therapeutic approaches.
Review in Clinical reviews in allergy & immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Whole exome sequencing of paediatric patients with Cogan's syndrome to identify monogenic mimics.Rheumatology (Oxford, England) · 2026Article
- Moyamoya Vasculopathy with Atypical Cogan's Syndrome: A Case Report.Archives of clinical and medical case reports · 2026Article
- Autoimmune Diseases and the Vestibular and Oculomotor System: Clinical Presentation, Diagnosis, and Treatment.Journal of eye movement research · 2026Review
- Rare primary vasculitis: update on multiple complex diseases and the new kids on the block.Advances in rheumatology (London, England) · 2024Review
- Prevalence of hearing loss, tinnitus, vertigo and sudden deafness among patients with polymyositis and dermatomyositis.Scientific reports · 2024Article
- Paediatric Cogan´s syndrome - review of literature, case report and practical approach to diagnosis and management.Pediatric rheumatology online journal · 2023Review
- Cogan's syndrome is more than just keratitis: a case-based literature review.BMC ophthalmology · 2023Article
- Cogan syndrome: a case report and review of the literature.Digital journal of ophthalmology : DJO · 2023Review
- Autoimmune Vestibulopathy-A Case Series.Brain sciences · 2022Article
- Pediatric uveitis: Role of the pediatrician.Frontiers in pediatrics · 2022Review
- Aortitis Secondary to Cogan's Syndrome: A Rare Cause of Fever of Unknown Origin.European journal of case reports in internal medicine · 2022Article
- The combined prevalence of classified rare rheumatic diseases is almost double that of ankylosing spondylitis.Orphanet journal of rare diseases · 2021Article
- Rare Diseases of the Orbit.Laryngo- rhino- otologie · 2021Review
- Clinically isolated descending thoracic aortitis in a healthy older woman: a diagnostic challenge.BMJ case reports · 2021Article
- Familial HLA-B*52 Vasculitis: Maternal, Atypical Cogan's Syndrome with Takayasu Arteritis-mimicking Aortitis and Filial Takayasu Arteritis.Internal medicine (Tokyo, Japan) · 2020Article
- Orbital Vasculitides-Differential Diagnosis.Current rheumatology reports · 2019Review
- Ear Involvement in Inflammatory Bowel Disease: A Review of the Literature.Journal of clinical medicine research · 2018Review
- Sudden sensorineural hearing loss in atypical Cogan's syndrome: A case report.Annals of medicine and surgery (2012) · 2018Article
- Optimal management of Cogan's syndrome: a multidisciplinary approach.Journal of multidisciplinary healthcare · 2018Review
- Update on Vertigo in Autoimmune Disorders, from Diagnosis to Treatment.Journal of immunology research · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cogan's syndrome (CS) is a rare chronic inflammatory disorder, classically characterized by interstitial keratitis and sensorineural hearing loss. Recurrent episodes of inner ear disease might result in deafness. In some patients, it may also be accompanied by systemic vasculitis. Diagnosis of CS is often missed or delayed due to its rarity, the nonspecific clinical signs at onset, and the lack of a confirmatory diagnostic test. The mechanisms responsible for CS are unknown; however, in the last decade, the pathogenesis has been somewhat elucidated, suggesting that the disease is a result of inner ear autoimmunity. The autoimmune hypothesis postulates the triggering of the disease by a viral infection via a number of mechanisms, which are mainly as follows: antigenic mimicry, self-perpetuating inflammation by cytokine release, and unveiling hidden epitopes. Aside from its clinical resemblance to other autoimmune disorders, some autoantigen has apparently been identified, namely, CD148 and connexine 26. Treatment should begin as early as possible. While treatment is based primarily on glucocorticoids, there is no standard alternative for patients who respond poorly. Failure of conventional treatment could lead to profound sensorineural hearing loss. From the limited data we have, infliximab seems to be the most promising biological remedy, enabling steroid tapering and leading to improvement in auditory/ocular disease, with better results when administered in early stages. Proposed guidelines for the use of infliximab in CS are found in the last table of the review, in an attempt to define the proper timing for initiating infliximab treatment in order to avoid permanent disability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.