SynthesisInternational journal of colorectal disease2014
Oncological superiority of extralevator abdominoperineal resection over conventional abdominoperineal resection: a meta-analysis.
Synthesis in International journal of colorectal disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Extralevator abdominoperineal excision versus abdominoperineal excision for low rectal cancer: a meta-analysis.Chinese medical journal · 2019Pooled it
- Rectal Cancer, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Standard versus extralevator abdominoperineal excision and oncologic outcomes for patients with distal rectal cancer: A meta-analysis.Medicine · 2017Pooled it
- A systematic review of transabdominal levator division during abdominoperineal excision of the rectum (APER).Techniques in coloproctology · 2017Pooled it
- Short- and mid-term outcomes of abdominoperineal resection with perineal mesh insertion: a single-centre experience.International journal of colorectal disease · 2023Article
- Locally Advanced Rectal Cancer: What We Learned in the Last Two Decades and the Future Perspectives.Journal of gastrointestinal cancer · 2023Review
- Inter sphincter rectal resection with and without Malone ante grade continence enema in cases with low rectal cancer: A randomized, prospective, single-blind, clinical trial.Caspian journal of internal medicine · 2022Article
- Transperineal minimally invasive APE: preliminary outcomes in a multicenter cohort.Techniques in coloproctology · 2020Article
- Rectal cancer lexicon: consensus statement from the society of abdominal radiology rectal & anal cancer disease-focused panel.Abdominal radiology (New York) · 2019Article
- State of the Art - Rectal Cancer Surgery.Visceral medicine · 2019Review
- Oncological outcomes of abdominoperineal resection for the treatment of low rectal cancer: A retrospective review of a single UK tertiary centre experience.Annals of medicine and surgery (2012) · 2018Article
- Local recurrence after 'standard' abdominoperineal resection: do we really need ELAPE?Annals of the Royal College of Surgeons of England · 2018Article
- Short-term surgical outcomes and patient quality of life between robotic and laparoscopic extralevator abdominoperineal excision for adenocarcinoma of the rectum.Annals of the Royal College of Surgeons of England · 2017Article
- Extralevator Abdominal Perineal Excision Versus Standard Abdominal Perineal Excision: Impact on Quality of the Resected Specimen and Postoperative Morbidity.World journal of surgery · 2017Article
- Oncological and quality of life outcomes following extralevator versus standard abdominoperineal excision for rectal cancer.Annals of the Royal College of Surgeons of England · 2017Article
- Long-term outcome of extralevator abdominoperineal excision (ELAPE) for low rectal cancer.International journal of colorectal disease · 2016Article
- Laparoscopic translevator approach to abdominoperineal resection for rectal adenocarcinoma: feasibility and short-term oncologic outcomes.Surgical endoscopy · 2016Article
- Short-term outcomes of the modified extralevator abdominoperineal resection for low rectal cancer (with videos).Surgical endoscopy · 2016Article
- Observational
- Extralevator abdominoperineal excision versus conventional surgery for low rectal cancer: a single surgeon experience.Ulusal cerrahi dergisi · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe oncological superiority, i.e., lower circumferential resection margin (CRM) involvement, lower intraoperative perforation (IOP), and local recurrence (LR) rates, of extralevator abdominoperineal resection (EAPR) over conventional abdominoperineal resection (APR) for rectal cancer is inconclusive. This meta-analysis systematically compared the rates of CRM involvement, IOP, and LR of rectal cancer patients treated by EAPR and APR, respectively.
methodsAn electronic literature search of MEDLINE, EMBASE, and Cochrane Library through May 2013 was performed by two investigators independently to identify studies evaluating the CRM involvement, IOP, and LR rates of EAPR and APR, and search results were cross-checked to reach a consensus. Data was extracted accordingly. A Mantel-Haenszel random effects model was used to calculate the odds ratio (OR) with 95 % confidence intervals (95 % CI).
resultsSix studies with a total of 881 patients were included. Meta-analysis of CRM involvement and IOP data from all six studies demonstrated significant lower CRM involvement (OR, 0.36; 95%CI, 0.23-0.58; P < 0.0001) and IOP (OR, 0.31; 95%CI, 0.12-0.80; P = 0.02) rates of EAPR. Data from four studies also showed that EAPR was associated with a lower LR rate than APR (OR, 0.27; 95%CI, 0.08-0.95; P = 0.04). No differences of between-study heterogeneity or publication bias were seen in any of the meta-analyses.
conclusionsExtralevator abdominoperineal resection could achieve better CRM involvement outcome and lower IOP and LR rates, demonstrating an oncological superiority over conventional abdominoperineal resection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.