ReviewModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2014
Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.
Review in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 4 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Systematic Review of the Literature in the Last 20 Years.Current oncology (Toronto, Ont.) · 2024Pooled it
- Leiomyosarcoma of the abdomen and retroperitoneum; a systematic review.Frontiers in surgery · 2024Pooled it
- Skull Base Leiomyomas and Angioleiomyomas: A Systematic Literature Review and an Uncommon Case Report.World neurosurgery · 2021Pooled it
- Sarcomas of the sellar region: a systematic review.Pituitary · 2021Pooled it
- Article
- Undifferentiated Pleomorphic Sarcoma with Dual Smooth-Muscle and Osteogenic Differentiation Mimicking Plasma Cell Dyscrasia: A Rare Diagnostic Pitfall.Journal of orthopaedic case reports · 2026Article
- Anterior Chest Wall Leiomyoma in a 4-Year-Old Girl: A Rare Pediatric Case.Clinical case reports · 2026Article
- Paratubal Leiomyoma Mimicking Ovarian Malignancy: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Identification of a novel minor-groove DNA binder that represses mitochondrial gene expression and induces apoptosis in highly aggressive leiomyosarcoma cells.Cell death discovery · 2025Article
- Primary pelvic retroperitoneal smooth muscle tumor with cystic degeneration: a case report and review of the literature.BMC women's health · 2025Review
- Epstein-Barr virus-associated smooth muscle tumor partially occluding the superior sagittal sinus: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Article
- A Lightweight Machine Learning Model for High Precision Gastrointestinal Stromal Tumors Identification.Bioengineering (Basel, Switzerland) · 2025Article
- The Impact of Li-Fraumeni and Germline Retinoblastoma Mutations on Leiomyosarcoma Initiation, Outcomes, and Genetic Testing Recommendations.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Primary omental smooth muscle tumor in an adult male: a diagnostic dilemma for leiomyoma: a case report.Journal of medical case reports · 2024Article
- Natural history of gastric leiomyoma.Surgical endoscopy · 2024Article
- Treatment of renal leiomyosarcoma with right atrial tumor embolus without cardiopulmonary bypass: a case report.Frontiers in oncology · 2024Article
- Epstein-Barr Virus-Positive Leiomyosarcoma in Immunocompetent Patients.Turk patoloji dergisi · 2024Article
- Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model.Frontiers in oncology · 2023Article
- Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Smooth muscle tumors are here considered an essentially dichotomous group composed of benign leiomyomas and malignant leiomyosarcomas. Soft tissue smooth muscle tumors with both atypia and mitotic activity are generally diagnosed leiomyosarcomas acknowledging potential for metastasis. However, lesions exist that cannot be comfortably placed in either category, and in such cases the designation 'smooth muscle tumor of uncertain biologic potential' is appropriate. The use of this category is often necessary with limited sampling, such as needle core biopsies. Benign smooth muscle tumors include smooth muscle hamartoma and angioleiomyoma. A specific category of leiomyomas are estrogen-receptor positive ones in women. These are similar to uterine leiomyomas and can occur anywhere in the abdomen and abdominal wall. Leiomyosarcomas can occur at any site, although are more frequent in the retroperitoneum and proximal extremities. They are recognized by likeness to smooth muscle cells but can undergo pleomorphic evolution ('dedifferentiation'). Presence of smooth muscle actin is nearly uniform and desmin-positivity usual. This and the lack of KIT expression separate leiomyosarcoma from GIST, an important problem in abdominal soft tissues. EBV-associated smooth muscle tumors are a specific subcategory occurring in AIDS or post-transplant patients. These tumors can have incomplete smooth muscle differentiation but show nuclear EBER as a diagnostic feature. In contrast to many other soft tissue tumors, genetics of smooth muscle tumors are poorly understood and such diagnostic testing is not yet generally applicable in this histogenetic group. Leiomyosarcomas are known to be genetically complex, often showing 'chaotic' karyotypes including aneuploidy or polyploidy, and no recurrent tumor-specific translocations have been detected.
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Registered trials
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