ArticleJournal of mathematical biology2014
Virus antibody dynamics in primary and secondary dengue infections.
Article in Journal of mathematical biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 67 citations in OpenAlex.
- A deterministic model for homologous antibody dependant enhancement on influenza infection.Infectious Disease Modelling · 2024Article
- Modelling the mechanisms of antibody mixtures in viral infections: the cases of sequential homologous and heterologous dengue infections.Journal of the Royal Society, Interface · 2024Article
- Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection.Journal of virology · 2024Article
- Global stability of secondary DENV infection models with non-specific and strain-specific CTLs.Heliyon · 2024Article
- Article
- Within Host Dynamics of SARS-CoV-2 in Humans: Modeling Immune Responses and Antiviral Treatments.SN computer science · 2021Article
- Autoantibody Profiling in Plasma of Dengue Virus-Infected Individuals.Pathogens (Basel, Switzerland) · 2020Article
- Within-host mechanisms of immune regulation explain the contrasting dynamics of two helminth species in both single and dual infections.PLoS computational biology · 2020Article
- Infection severity across scales in multi-strain immuno-epidemiological Dengue model structured by host antibody level.Journal of mathematical biology · 2020Article
- Modelling the impact of antibody-dependent enhancement on disease severity of Zika virus and dengue virus sequential and co-infection.Royal Society open science · 2020Article
- Challenges in dengue research: A computational perspective.Evolutionary applications · 2018Review
- Simulation Model for Dynamics of Dengue with Innate and Humoral Immune Responses.Computational and mathematical methods in medicine · 2018Article
- Mathematical Modelling of Immune Parameters in the Evolution of Severe Dengue.Computational and mathematical methods in medicine · 2017Article
- Arbovirosis and potential transmission blocking vaccines.Parasites & vectors · 2016Review
- Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections.Journal of the Royal Society, Interface · 2015Article
- Within-host viral dynamics of dengue serotype 1 infection.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue viral infections show unique infection patterns arising from its four serotypes, (DENV-1,2,3,4). Its effects range from simple fever in primary infections to potentially fatal secondary infections. We analytically and numerically analyse virus dynamics and humoral response in a host during primary and secondary dengue infection for long periods using micro-epidemic models. The models presented here incorporate time delays, antibody dependent enhancement, a dynamic switch and a correlation factor between different DENV serotypes. We find that the viral load goes down to undetectable levels within 7-14 days as is observed for dengue infection, in both cases. For primary infection, the stability analysis of steady states shows interesting dependence on the time delay involved in the production of antibodies from plasma cells. We demonstrate the existence of a critical value for the immune response parameter, beyond which the infection gets completely cured. For secondary infections with a different serotype, the homologous antibody production is enhanced due to the influence of heterologous antibodies. The antibody production is also controlled by the correlation factor, which is a measure of similarities between the different DENV serotypes involved. Our results agree with clinically observed humoral responses for primary and secondary infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.