Evidence map›Paper›PMID 24384598›Full record

ReviewNature reviews. Microbiology2014

Cell division in apicomplexan parasites.

Maria E Francia, Boris Striepen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 303 citations in OpenAlex.

  1. Putative binding ofVeterinary and animal science · 2026
    Article
  2. Toxoplasma gondii SIR2A Promotes Tachyzoite Invasion via Lysine Deacetylase Activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
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  9. Organelle scaling over a 100-fold cell size range.bioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. The Centrocone Protein SMC_N1 Is Important for the Proliferation ofAnimals : an open access journal from MDPI · 2026
    Article
  12. Review
  13. mBio · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. bioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria E FranciaDepartment of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA.
Boris Striepen1] Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA. [2] Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, USA.
University of Georgia · US

Funding

Biology of the Apicomplexan PlastidR01AI064671 · NIAID · UNIVERSITY OF GEORGIA · PI STRIEPEN, BORIS · 2006 to 2015
$3.1M
Centrosome control of Toxoplasma growthR01AI109843 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2014 to 2018
$2.4M
Essential Cell Cycle Mechanisms in ToxoplasmaR01AI077662 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI WHITE, MICHAEL W · 2009 to 2013
$1.8M
NIAID NIH HHS R01 AI064671NIAID NIH HHS R01 AI077662NIAID NIH HHS R01 AI109843
6 · The paper itself

Abstract

Toxoplasma gondii and Plasmodium falciparum are important human pathogens. These parasites and many of their apicomplexan relatives undergo a complex developmental process in the cells of their hosts, which includes genome replication, cell division and the assembly of new invasive stages. Apicomplexan cell cycle progression is both globally and locally regulated. Global regulation is carried out throughout the cytoplasm by diffusible factors that include cell cycle-specific kinases, cyclins and transcription factors. Local regulation acts on individual nuclei and daughter cells that are developing inside the mother cell. We propose that the centrosome is a master regulator that physically tethers cellular components and that provides spatial and temporal control of apicomplexan cell division.

Indexed as

Cell DivisionAnimalsApicomplexaCell NucleusCentrosomeDNA ReplicationHumansMalaria, FalciparumModels, BiologicalPlasmodium falciparumProtozoan InfectionsProtozoan ProteinsToxoplasmaToxoplasmosisProtozoan Proteins

Identifiers

PMID24384598
OpenAlexW1976112747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.