ArticleNeuroreport2014
Estimation of the spatial profile of neuromodulation and the temporal latency in motor responses induced by focused ultrasound brain stimulation.
Article in Neuroreport, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain Modulatory Effects by Low-Intensity Transcranial Ultrasound Stimulation (TUS): A Systematic Review on Both Animal and Human Studies.Frontiers in neuroscience · 2019Pooled it
- Trial
- Ultrasound Modulation of Visual Circuits in Mice Independent of Auditory Confound.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Low-intensity transcranial focused ultrasound of the amygdala modulates neural activation during emotion processing.Frontiers in neuroimaging · 2025Article
- Modulation of cardio-respiratory activity in mice via transcranial focused ultrasound.Ultrasound in medicine & biology · 2024Article
- Image-Guided Measurement of Radiation Force Induced by Focused Ultrasound Beams.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
- Transcranial ultrasound neuromodulation induces neuronal correlation change in the rat somatosensory cortex.Journal of neural engineering · 2022Article
- Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation.Frontiers in human neuroscience · 2022Review
- Modulating the Blood-Brain Barrier: A Comprehensive Review.Pharmaceutics · 2021Review
- Transcranial focused ultrasound modulates cortical and thalamic motor activity in awake sheep.Scientific reports · 2021Article
- High-Resolution Focused Ultrasound Neuromodulation Induces Limb-Specific Motor Responses in Mice in Vivo.Ultrasound in medicine & biology · 2021Article
- Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis.Micromachines · 2020Review
- Neuromodulation Management of Chronic Neuropathic Pain in The Central Nervous system.Advanced functional materials · 2020Article
- Ultrasonic Neuromodulation and Sonogenetics: A New Era for Neural Modulation.Frontiers in physiology · 2020Review
- Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans.Frontiers in human neuroscience · 2020Article
- Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety.Ultrasound in medicine & biology · 2019Review
- A review on ultrasonic neuromodulation of the peripheral nervous system: enhanced or suppressed activities?Applied sciences (Basel, Switzerland) · 2019Article
- Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model.PloS one · 2019Article
- Comparative Study of Transcranial Magneto-Acoustic Stimulation and Transcranial Ultrasound Stimulation of Motor Cortex.Frontiers in behavioral neuroscience · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study investigates the spatial profile and the temporal latency of the brain stimulation induced by the transcranial application of pulsed focused ultrasound (FUS). The site of neuromodulation was detected using 2-deoxy-2-[¹⁸F]fluoro-D-glucose PET immediately after FUS sonication on the unilateral thalamic area of Sprague-Dawley rats. The latency of the stimulation was estimated by measuring the time taken from the onset of the stimulation of the appropriate brain motor area to the corresponding tail motor response. The brain area showing elevated glucose uptake from the PET image was much smaller (56±10% in diameter, 24±6% in length) than the size of the acoustic focus, which is conventionally defined by the full-width at half-maximum of the acoustic intensity field. The spatial dimension of the FUS-mediated neuromodulatory area was more localized, approximated to be full-width at 90%-maximum of the acoustic intensity field. In addition, the time delay of motor responses elicited by the FUS sonication was 171±63 (SD) ms from the onset of sonication. When compared with latencies of other nonultrasonic neurostimulation techniques, the longer time delay associated with FUS-mediated motor responses is suggestive of the nonelectrical modes of neuromodulation, making it a distinctive brain stimulation method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.