ArticleExperimental gerontology2014
Patterns of intraspecific variability in the response to caloric restriction.
Article in Experimental gerontology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Maternal effect senescence and caloric restriction interact to affect fitness through changes in life history timing.The Journal of animal ecology · 2025Article
- Maternal age effects on offspring lifespan and reproduction vary within a species.Ecology and evolution · 2024Article
- Resource allocation strategies for survival and reproduction by an invasive pest in response to intermittent fasting.Current zoology · 2023Article
- Brachionus rotifers as a model for investigating dietary and metabolic regulators of aging.Nutrition and healthy aging · 2021Review
- Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction.Scientific reports · 2019Article
- Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature.Experimental gerontology · 2018Article
- When males outlive females: Sex-specific effects of temperature on lifespan in a cyclic parthenogen.Ecology and evolution · 2018Article
- Shifts in rotifer life history in response to stable isotope enrichment: testing theories of isotope effects on organismal growth.Royal Society open science · 2017Article
- Genome-wide transcriptomics of aging in the rotifer Brachionus manjavacas, an emerging model system.BMC genomics · 2017Article
- Measurement of Survival Time in Brachionus Rotifers: Synchronization of Maternal Conditions.Journal of visualized experiments : JoVE · 2016Article
- Moderately lower temperatures greatly extend the lifespan of Brachionus manjavacas (Rotifera): Thermodynamics or gene regulation?Experimental gerontology · 2016Article
- Rotifers as experimental tools for investigating aging.Invertebrate reproduction & development · 2015Article
- Maternal caloric restriction partially rescues the deleterious effects of advanced maternal age on offspring.Aging cell · 2014Article
- Joint inhibition of TOR and JNK pathways interacts to extend the lifespan of Brachionus manjavacas (Rotifera).Experimental gerontology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Caloric restriction (CR) is cited as the most robust means of increasing lifespan across a range of taxa, yet there is a high degree of variability in the response to CR, both within and between species. To examine the intraspecific evolutionary conservation of lifespan extension by CR, we tested the effects of chronic caloric restriction (CCR) at multiple food levels and of intermittent fasting (IF) in twelve isolates from the Brachionus plicatilis species complex of monogonont rotifers. While CCR generally increased or did not change lifespan and total fecundity, IF caused increased, unchanged, or decreased lifespan, depending upon the isolate, and decreased total fecundity in all but one isolate. Lifespan under ad libitum (AL) feeding varied among isolates and predicted the lifespan response to CR: longer-lived isolates under AL were less likely to have a significant increase in lifespan under CCR and were more likely to have a significantly shortened lifespan under IF. Lifespan under AL conditions and the response to CR were not correlated with hydroperiodicity of native habitat or with time in culture. Lack of trade-off between lifespan and fecundity under CCR, and differences in lifespan and fecundity under CCR and IF, even when average food intake was similar, suggest that longevity changes are not always directly determined by energy intake and that CCR and IF regimens extend lifespan through diverse genetic mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.