ArticlePhysiology & behavior2014
Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice.
Article in Physiology & behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 41 citations in OpenAlex.
- Noncanonical Taste Transduction of Sugars Elicits Responses in a Dedicated Subset of Gustatory Afferent Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Immediate glucose signaling transmitted via the vagus nerve in gut-brain neural communication.iScience · 2025Article
- The impact of caloric availability on eating behavior and ultra-processed food reward.Appetite · 2022Article
- Interactions between central nervous system and peripheral metabolic organs.Science China. Life sciences · 2022Review
- Gut-brain circuits for fat preference.Nature · 2022Article
- Fat preference deficits and experience-induced recovery in global taste-deficient Trpm5 and Calhm1 knockout mice.Physiology & behavior · 2022Article
- Molecular aspects of fructose metabolism and metabolic disease.Cell metabolism · 2021Review
- Sucralose and Cardiometabolic Health: Current Understanding from Receptors to Clinical Investigations.Advances in nutrition (Bethesda, Md.) · 2021Review
- The gut-brain axis: Identifying new therapeutic approaches for type 2 diabetes, obesity, and related disorders.Molecular metabolism · 2021Review
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
- Nutrient-conditioned intake stimulation does not require a distinctive flavor cue in rats.Appetite · 2020Article
- Sugar causes obesity and metabolic syndrome in mice independently of sweet taste.American journal of physiology. Endocrinology and metabolism · 2020Article
- Residual Glucose Taste in T1R3 Knockout but not TRPM5 Knockout Mice.Physiology & behavior · 2020Article
- The gut-brain axis mediates sugar preference.Nature · 2020Article
- T1R2+T1R3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Calhm2 governs astrocytic ATP releasing in the development of depression-like behaviors.Molecular psychiatry · 2018Article
- TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALB/c Mice.BioMed research international · 2018Article
- Amino acid sensing in hypothalamic tanycytes via umami taste receptors.Molecular metabolism · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The present study compared the ability of sweet ageusic T1r3 knockout (KO) and Calhm1 KO mice to acquire preferences for a sucrose-paired flavor as well as for unflavored sucrose. The KO and wildtype (WT) mice were given 24-h one-bottle access to 8% sucrose containing one flavor CS+, e.g., grape) and to water containing a different flavor (CS-, e.g., cherry) over 4 training days. In subsequent two-bottle tests with the flavors in water only, the T1r3 KO and Calhm1 KO mice, like WT mice, preferred the CS+ to the CS-. After training with flavored solutions, both KO groups also preferred unflavored 8% sucrose to water although Calhm1 KO mice required more sugar experience to match the preference of the T1r3 KO mice. These findings demonstrate that Calhm1 KO mice, like T1r3 KO mice and WT mice, are sensitive to the post-oral preference conditioning actions of sucrose and can discriminate sugar from water. Yet, despite their acquired sucrose preferences, the Calhm1 KO and T1r3 KO mice consumed only half as much sugar per day as did WT mice. Thus, sweet taste signaling elements are not needed in the gut for sugar conditioning, but sweet taste signaling in the mouth is essential for the full expression of sugar appetite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.