ArticleActa biomaterialia2014
Magnesium alloys as a biomaterial for degradable craniofacial screws.
Article in Acta biomaterialia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 135 citations in OpenAlex.
- Current status and future prospects of biodegradable magnesium-based implants developed for orthopaedic applications.Journal of orthopaedic translation · 2026Review
- An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion.Bioactive materials · 2024Review
- Functional engineering strategies of 3D printed implants for hard tissue replacement.Regenerative biomaterials · 2023Review
- Applications of Biodegradable Magnesium-Based Materials in Reconstructive Oral and Maxillofacial Surgery: A Review.Molecules (Basel, Switzerland) · 2022Review
- In vivo performance of a rare earth free Mg-Zn-Ca alloy manufactured using twin roll casting for potential applications in the cranial and maxillofacial fixation devices.Bioactive materials · 2022Article
- Article
- Research status of biodegradable metals designed for oral and maxillofacial applications: A review.Bioactive materials · 2021Review
- Biodegradable metals for bone defect repair: A systematic review and meta-analysis based on animal studies.Bioactive materials · 2021Review
- Biodegradable magnesium-based biomaterials: An overview of challenges and opportunities.MedComm · 2021Review
- Mg/ZrOFrontiers in bioengineering and biotechnology · 2021Article
- Exposure to high levels of magnesium disrupts bone mineralizationAnnals of translational medicine · 2020Article
- Bioabsorbable high-purity magnesium interbody cage: degradation, interbody fusion, and biocompatibility from a goat cervical spine model.Annals of translational medicine · 2020Article
- Biodegradable Magnesium-Based Implants in Orthopedics-A General Review and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Additive manufacturing of magnesium alloys.Bioactive materials · 2020Review
- Alloying design of biodegradable zinc as promising bone implants for load-bearing applications.Nature communications · 2020Article
- Translational status of biomedical Mg devices in China.Bioactive materials · 2019Article
- Improved corrosion resistance of commercially pure magnesium after its modification by plasma electrolytic oxidation with organic additives.Journal of biomaterials applications · 2018Article
- In vitro corrosion of pure magnesium and AZ91 alloy-the influence of thin electrolyte layer thickness.Regenerative biomaterials · 2016Article
- Varying degrees of nonlinear mechanical behavior arising from geometric differences of urogynecological meshes.Journal of biomechanics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Recently, magnesium (Mg) alloys have received significant attention as potential biomaterials for degradable implants, and this study was directed at evaluating the suitability of Mg for craniofacial bone screws. The objective was to implant screws fabricated from commercially available pure Mg and alloy AZ31 in vivo in a rabbit mandible. First, Mg and AZ31 screws were compared to stainless steel screws in an in vitro pull-out test and determined to have a similar holding strength (∼40N). A finite-element model of the screw was created using the pull-out test data, and this model can be used for future Mg alloy screw design. Then, Mg and AZ31 screws were implanted for 4, 8 and 12weeks, with two controls of an osteotomy site (hole) with no implant and a stainless steel screw implanted for 12weeks. Microcomputed tomography was used to assess bone remodeling and Mg/AZ31 degradation, both visually and qualitatively through volume fraction measurements for all time points. Histological analysis was also completed for the Mg and AZ31 at 12weeks. The results showed that craniofacial bone remodeling occurred around both Mg and AZ31 screws. Pure Mg had a different degradation profile than AZ31; however, bone growth occurred around both screw types. The degradation rate of both Mg and AZ31 screws in the bone marrow space and the muscle were faster than in the cortical bone space at 12weeks. Furthermore, it was shown that by alloying Mg, the degradation profile could be changed. These results indicate the promise of using Mg alloys for craniofacial applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.