ArticleJournal of the American Geriatrics Society2014
Associations between bone mineral density, grip strength, and lead body burden in older men.
Article in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- High-Intensity Interval Circuit Training Versus Moderate-Intensity Continuous Training on Functional Ability and Body Mass Index in Middle-Aged and Older Women: A Randomized Controlled Trial.International journal of environmental research and public health · 2019Trial
- Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.Biological trace element research · 2025Article
- Lead exposure and physical frailty in patients with type 2 diabetes mellitus: cross-sectional results from the METAL study.Endocrine · 2025Article
- Influence ofInternational journal of environmental research and public health · 2023Article
- Association between Outdoor Air Pollution Exposure and Handgrip Strength: Findings from the French CONSTANCES Study.Environmental health perspectives · 2022Article
- Article
- Metal exposure and bone remodeling during pregnancy: Results from the PROGRESS cohort study.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Association between Phthalate Exposure and Frailty among Community-Dwelling Older Adults: A Repeated Panel Data Study.International journal of environmental research and public health · 2021Article
- Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs.Environmental science and pollution research international · 2020Review
- Nuclear receptor and VEGF pathways for gene-blood lead interactions, on bone mineral density, in Korean smokers.PloS one · 2018Article
- Environmental Pollutants, Limitations in Physical Functioning, and Frailty in Older Adults.Current environmental health reports · 2017Review
- Cognitive Differences between Men and Women who Fracture their Hip and Impact on Six-Month Survival.Journal of the American Geriatrics Society · 2017Article
- Osteoporosis in men: findings from the Osteoporotic Fractures in Men Study (MrOS).Therapeutic advances in musculoskeletal disease · 2016Review
- Evaluation and management of lead exposure.Annals of occupational and environmental medicine · 2015Review
- Correlation between bone mineral density and serum trace element contents of elderly males in Beijing urban area.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo study the association between blood lead concentration (BPb) and bone mineral density (BMD), physical function, and cognitive function in noninstitutionalized community-dwelling older men.
designCross-sectional study.
settingUniversity of Pittsburgh clinic, Pittsburgh, Pennsylvania.
participantsNon-Hispanic Caucasian men aged 65 and older (N = 445) recruited as a subset of a prospective cohort for the Osteoporotic Fractures in Men Study. MEASUREMENTS: BPb was measured in 2007/08. From 2007 to 2009, BMD (g/cm(2)) was measured using dual-energy X-ray absorptiometry. At the same time, physical performance was measured using five tests: grip strength, leg extension power, walking speed, narrow-walk pace, and chair stands. Cognitive performance was assessed using the modified Mini-Mental State Examination and the Trail-Making Test Part B. Participants were categorized into quartiles of BPb. Multivariate regression analysis was used to evaluate the independent relationship between BPb, BMD, and cognitive and physical function.
resultsMean BPb ± standard deviation was 2.25 ± 1.20 μg/dL (median 2 μg/dL, range 1-10 μg/dL). In multivariate-adjusted models, men in higher BPb quartiles had lower BMD at femoral neck and total hip (P-trend < .001 for both). Men with higher BPb had lower age-adjusted score for grip strength (P-trend < .001), although this association was not significant in multivariate-adjusted models (P-trend < .15). BPb was not associated with lumbar spine BMD, cognition, leg extension power, walking speed, narrow-walk pace, or chair stands.
conclusionEnvironmental lead exposure may adversely affect bone health in older men. These findings support consideration of environmental exposure in age-associated bone fragility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.