Observational studyCardiovascular diabetology2014
Relationship of obesity and insulin resistance with the cerebrovascular reactivity: a case control study.
Observational study in Cardiovascular diabetology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Evaluation of cerebrovascular reactivity using transcranial Doppler in patients with influenza.PloS one · 2026Article
- A systematic review of in vivo brain insulin resistance biomarkers in humans.Biomarkers in neuropsychiatry · 2025Review
- Early Cerebral Microvasculature Impairment and Increased Body Mass Index in Patients with Psoriasis.Biomedicines · 2024Article
- Impact of Fat Distribution and Metabolic Diseases on Cerebral Microcirculation: A Multimodal Study on Type 2 Diabetic and Obese Patients.Journal of clinical medicine · 2024Article
- Evaluation of Cerebral Vasomotor Reactivity by Transcranial Doppler Ultrasound in Patients with Diabetic Retinopathy.Neuro-ophthalmology (Aeolus Press) · 2023Article
- New Horizons: Next-Generation Insulin Analogues: Structural Principles and Clinical Goals.The Journal of clinical endocrinology and metabolism · 2022Review
- Higher body mass index is associated with worse hippocampal vasoreactivity to carbon dioxide.Frontiers in aging neuroscience · 2022Article
- Structural principles of insulin formulation and analog design: A century of innovation.Molecular metabolism · 2021Review
- Gut Microbiome, Inflammation, and Cerebrovascular Function: Link Between Obesity and Cognition.Frontiers in neuroscience · 2021Review
- Article
- Sex-specific effects of high-fat diet on cognitive impairment in a mouse model of VCID.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Impact of bariatric surgery on cerebral vascular reactivity and cognitive function: a non-randomized pilot study.Pilot and feasibility studies · 2020Article
- Exploring Cerebrovascular Function in Osteoarthritis: "Heads-up".Physiological reports · 2019Article
- Obstructive Sleep Apnea and Cognitive Decline in Older Adults.American journal of respiratory and critical care medicine · 2019Article
- Evaluation of cerebrovascular reactivity in chronic hepatitis C patients using transcranial color Doppler.PloS one · 2019Observational
- Can Curcumin Counteract Cognitive Decline? Clinical Trial Evidence and Rationale for Combining ω-3 Fatty Acids with Curcumin.Advances in nutrition (Bethesda, Md.) · 2018Review
- Insulin resistance in ischemic stroke.Metabolic brain disease · 2017Review
- Insulin resistance among obese middle-aged is associated with decreased cerebrovascular reactivity.Neurology · 2017Article
- Factors associated with young adults' knowledge regarding family history of Stroke.Revista latino-americana de enfermagem · 2016Article
- Association between metabolic syndrome and multiple lesions of intracranial atherothrombotic stroke: a hospital-based study.Cardiovascular diabetology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity is associated with increased risk for stroke. The breath-holding index (BHI) is a measure of vasomotor reactivity of the brain which can be measured with the transcranial Doppler (TCD). We aim to evaluate obesity as an independent factor for altered cerebrovascular reactivity.
methodsCerebrovascular hemodynamics (mean flow velocities MFV, pulsatility index, PI, resistance index, RI, and BHI) was determined in 85 non-obese (Body Mass Index, BMI ≤27 kg/m2) and 85 obese subjects (BMI ≥35 kg/m2) without diabetes mellitus and hypertension. Anthropometric and metabolic variables, and scores to detect risk for obstructive sleep apnea (OSA) were analyzed for their association with the cerebrovascular reactivity.
resultsThe BHI was significantly lower in subjects with obesity according to BMI and in subjects with abdominal obesity, but the PI and RI were not different between groups. There was a linear association between the BMI, the HOMA-IR, the Matsuda index, the waist circumference, and the neck circumference, with the cerebrovascular reactivity. After adjusting for insulin resistance, neck circumference, and abdominal circumference, obesity according to BMI was negatively correlated with the cerebrovascular reactivity.
conclusionsWe found a diminished vasomotor reactivity in individuals with obesity which was not explained by the presence of insulin resistance.
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Registered trials
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