Evidence map›Paper›PMID 24383882›Full record

ReviewBiochemistry2014

The renaissance of bacillosamine and its derivatives: pathway characterization and implications in pathogenicity.

Michael J Morrison, Barbara Imperiali

Open access · bronzeAbstract readReview
In one paragraph

Review in Biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
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  12. Defining Early Steps inbioRxiv : the preprint server for biology · 2023
    Article
  13. Review
  14. Article
  15. Review
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  17. Giant viruses of themicroLife · 2022
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Michael J MorrisonDepartments of Chemistry and Biology, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Barbara Imperiali
Massachusetts Institute of Technology · US

Funding

Interdepartmental Biotechnology Training ProgramT32GM008334 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WITTRUP, KARL DANE · 1989 to 2018
$15.2M
Inhibition of Prokaryote-Specific Saccharide Biosynthesis in Microbial PathogensR01GM097241 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IMPERIALI, BARBARA · 2012 to 2017
$1.8M
NIGMS NIH HHS GM097241NIGMS NIH HHS R01 GM097241NIGMS NIH HHS T32-GM08334
6 · The paper itself

Abstract

Prokaryote-specific sugars, including N,N'-diacetylbacillosamine (diNAcBac) and pseudaminic acid, have experienced a renaissance in the past decade because of their discovery in glycans related to microbial pathogenicity. DiNAcBac is found at the reducing end of oligosaccharides of N- and O-linked bacterial protein glycosylation pathways of Gram-negative pathogens, including Campylobacter jejuni and Neisseria gonorrhoeae. Further derivatization of diNAcBac results in the nonulosonic acid known as legionaminic acid, which was first characterized in the O-antigen of the lipopolysaccharide (LPS) in Legionella pneumophila. Pseudaminic acid, an isomer of legionaminic acid, is also important in pathogenic bacteria such as Helicobacter pylori because of its occurrence in O-linked glycosylation of flagellin proteins, which plays an important role in flagellar assembly and motility. Here, we present recent advances in the characterization of the biosynthetic pathways leading to these highly modified sugars and investigation of the roles that each plays in bacterial fitness and pathogenicity.

Indexed as

AcetylglucosamineAcyltransferasesBacteriaBacterial ProteinsGlycoproteinsGlycosylationHydro-LyasesProtein ConformationSugar AcidsTransaminasesVirulence Factors2,4-diacetamido-2,4,6-trideoxyglucopyranose5,7-diacetamido-3,5,7,9-tetradeoxynonulosonic acidAcetylglucosamineAcyltransferasesBacterial ProteinsGlycoproteinsHydro-LyasesSugar AcidsTransaminasesVirulence Factors

Identifiers

PMID24383882
PMCPMC3951908
OpenAlexW2126642157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.