ArticleRadiation oncology (London, England)2014
Range modulation in proton therapy planning: a simple method for mitigating effects of increased relative biological effectiveness at the end-of-range of clinical proton beams.
Article in Radiation oncology (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Reduced beam time and distal linear energy transfer with mini-ridge filters in pencil beam scanning proton therapy.Physics and imaging in radiation oncology · 2026Article
- Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2022Article
- Treatment planning for proton therapy: what is needed in the next 10 years?The British journal of radiology · 2020Review
- Charged-particle therapy in cancer: clinical uses and future perspectives.Nature reviews. Clinical oncology · 2017Review
- Proton therapy for paediatric CNS tumours - improving treatment-related outcomes.Nature reviews. Neurology · 2016Review
- Quantifying Proton Fields for Midline Brain Tumors: A Benefit/Cost Analysis of Planning Objectives.International journal of particle therapy · 2016Article
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Authors and funding
9 authors.
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Abstract
backgroundThe increase in relative biological effectiveness (RBE) of proton beams at the distal edge of the spread out Bragg peak (SOBP) is a well-known phenomenon that is difficult to quantify accurately in vivo. For purposes of treatment planning, disallowing the distal SOBP to fall within vulnerable tissues hampers sparing to the extent possible with proton beam therapy (PBT). We propose the distal RBE uncertainty may be straightforwardly mitigated with a technique we call "range modulation". With range modulation, the distal falloff is smeared, reducing both the dose and average RBE over the terminal few millimeters of the SOBP.
methodsOne patient plan was selected to serve as an example for direct comparison of image-guided radiotherapy plans using non-range modulation PBT (NRMPBT), and range-modulation PBT (RMPBT). An additional plan using RMPBT was created to represent a re-treatment scenario (RMPBTrt) using a vertex beam. Planning statistics regarding dose, volume of the planning targets, and color images of the plans are shown.
resultsThe three plans generated for this patient reveal that in all cases dosimetric and device manufacturing advantages are able to be achieved using RMPBT. Organ at risk (OAR) doses to critical structures such as the cochleae, optic apparatus, hypothalamus, and temporal lobes can be selectively spared using this method. Concerns about the location of the RBE that did significantly impact beam selection and treatment planning no longer have the same impact on the process, allowing these structures to be spared dose and subsequent associated issues.
conclusionsThis present study has illustrated that RMPBT can improve OAR sparing while giving equivalent coverage to target volumes relative to traditional PBT methods while avoiding the increased RBE at the end of the beam. It has proven easy to design and implement and robust in our planning process. The method underscores the need to optimize treatment plans in PBT for both traditional energy dose in gray (Gy) and biologic dose (RBE).
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