ArticleNutrition & metabolism2014
Disintegration of wheat aleurone structure has an impact on the bioavailability of phenolic compounds and other phytochemicals as evidenced by altered urinary metabolite profile of diet-induced obese mice.
Article in Nutrition & metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 154 citations in OpenAlex.
- Excretion of Avenanthramides, Phenolic Acids and their Major Metabolites Following Intake of Oat Bran.Molecular nutrition & food research · 2018Trial
- Trial
- Xylanase and phytase as modulators of gut microbiota and phytate degradation in wheat-based diets for meat quail.Poultry science · 2026Article
- Bio-Accessibility of Phenolic Compounds from Green Banana-Fortified Bread During Simulated Digestion and Colonic Fermentation.Molecules (Basel, Switzerland) · 2025Article
- From wheat bran to equine gut: theFrontiers in physiology · 2025Article
- Bioaccessibility of Phenolic Compounds, Resistant Starch, and Dietary Fibers from Australian Green Banana during In Vitro Digestion and Colonic Fermentation.Molecules (Basel, Switzerland) · 2024Article
- The Role of Genistein in Mammalian Reproduction.Molecules (Basel, Switzerland) · 2023Review
- A Comprehensive Review of Phytonutrients as a Dietary Therapy for Obesity.Foods (Basel, Switzerland) · 2023Review
- Phenolic Biotransformations in Wheatgrass Juice after Primary and Secondary Fermentation.Foods (Basel, Switzerland) · 2023Article
- Changes in the Bioaccessibility of Antioxidants after Simulated In Vitro Digestion of Bioprocessed Spelt-Enhanced Wheat Bread.Antioxidants (Basel, Switzerland) · 2023Article
- In Vitro Gastrointestinal Bioaccessibility, Bioactivities and Colonic Fermentation of Phenolic Compounds in DifferentFoods (Basel, Switzerland) · 2022Article
- The Wheat Aleurone Layer: Optimisation of Its Benefits and Application to Bakery Products.Foods (Basel, Switzerland) · 2022Review
- Lactic Acid Bacteria Simultaneously Encapsulate Diverse Bioactive Compounds from a Fruit Extract and Enhance Thermal Stability.Molecules (Basel, Switzerland) · 2022Article
- Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition.Scientific reports · 2022Article
- Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols.Journal of the science of food and agriculture · 2022Review
- Process-Induced Changes in the Quantity and Characteristics of Grain Dietary Fiber.Foods (Basel, Switzerland) · 2021Review
- Food Processing Technologies to Develop Functional Foods With Enriched Bioactive Phenolic Compounds in Cereals.Frontiers in plant science · 2021Review
- Effects of Aleurone Supplementation on Glucose-Insulin Metabolism and Gut Microbiome in Untrained Healthy Horses.Frontiers in veterinary science · 2021Article
- Side-stream products of malting: a neglected source of phytochemicals.NPJ science of food · 2020Article
- Factors affecting intake, metabolism and health benefits of phenolic acids: do we understand individual variability?European journal of nutrition · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhenolic acids are covalently bound to the arabinoxylan fibre matrix of wheat aleurone layer. In order to be bioavailable they need to be released by endogenous or bacterial enzymes and absorbed within the intestinal lumen. The intestinal microbiota can metabolize phenolic acids and other food-born phytochemicals. However, the effect of structure of the cereal bran or aleurone layer on these processes is not comprehensively studied.
methodsThe structure of aleurone layer was modified either by dry-grinding or by enzymatic treatments with xylanase alone or in combination with feruloyl esterase. Diet induced obese C57BL6/J mice were fed with high-fat diets containing either pure ferulic acid, or one of the four differentially treated aleurone preparations for 8 weeks. The diets were designed to be isocaloric and to have similar macronutrient composition. The urinary metabolite profiles were investigated using non-targeted LC-qTOF-MS-metabolomics approach.
resultsThe different dietary groups were clearly separated in the principal component analysis. Enzymatic processing of aleurone caused increased excretion of ferulic acid sulfate and glycine conjugates reflecting the increase in unbound form of readily soluble ferulic acid in the diet. The urinary metabolite profile of the diet groups containing native and cryo-ground aleurone was more intense with metabolites derived from microbial processing including hippuric acid, hydroxyl- and dihydroxyphenylpropionic acids. Furthermore, aleurone induced specific fingerprint on the urinary metabolite profile seen as excretion of benzoxazinoid metabolites, several small dicarboyxlic acids, and various small nitrogen containing compounds.
conclusionsThe structural modifications on wheat aleurone fraction resulted in altered metabolism of aleurone derived phenolic acids and other phytochemicals excreted in urine of diet-induced obese mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.