ArticleHuman brain mapping2014
Flexible connectivity in the aging brain revealed by task modulations.
Article in Human brain mapping, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Mnemonic brain state engagement is diminished in healthy aging.Neurobiology of aging · 2025Article
- Article
- Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.Brain structure & function · 2024Article
- Differential spatial working memory-related functional network reconfiguration in young and older adults.Network neuroscience (Cambridge, Mass.) · 2024Article
- Effects of Mild Traumatic Brain Injury on Resting State Brain Network Connectivity in Older Adults.Brain imaging and behavior · 2022Article
- Neural Correlates of Enhanced Memory for Meaningful Associations with Age.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Resting-state and Vocabulary Tasks Distinctively Inform On Age-Related Differences in the Functional Brain Connectome.Language, cognition and neuroscience · 2019Article
- Reduced Syntactic Processing Efficiency in Older Adults During Sentence Comprehension.Frontiers in psychology · 2018Article
- Visuotactile interaction even in far sagittal space in older adults with decreased gait and balance functions.Experimental brain research · 2017Article
- Age-Related Differences in Reorganization of Functional Connectivity for a Dual Task with Increasing Postural Destabilization.Frontiers in aging neuroscience · 2017Article
- The use of resting state data in an integrative approach to studying neurocognitive ageing - Commentary on Campbell and Schacter (2016).Language, cognition and neuroscience · 2017Article
- Age-Related Differences in Dynamic Interactions Among Default Mode, Frontoparietal Control, and Dorsal Attention Networks during Resting-State and Interference Resolution.Frontiers in aging neuroscience · 2017Article
- Longitudinal Evidence for Dissociation of Anterior and Posterior MTL Resting-State Connectivity in Aging: Links to Perfusion and Memory.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Reconfiguration of brain network architecture to support executive control in aging.Neurobiology of aging · 2016Article
- Gender Specific Re-organization of Resting-State Networks in Older Age.Frontiers in aging neuroscience · 2016Article
- Article
- Progressive Bidirectional Age-Related Changes in Default Mode Network Effective Connectivity across Six Decades.Frontiers in aging neuroscience · 2016Article
- Age-Related Differences in the Modulation of Small-World Brain Networks during a Go/NoGo Task.Frontiers in aging neuroscience · 2016Article
- Implicit Motor Sequence Learning and Working Memory Performance Changes Across the Adult Life Span.Frontiers in aging neuroscience · 2016Article
- Decreased activity with increased background network efficiency in amnestic MCI during a visuospatial working memory task.Human brain mapping · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have shown that aging has a large impact on connectivity within and between functional networks. An open question is whether elderly still have the flexibility to adapt functional network connectivity (FNC) to the demands of the task at hand. To study this, we collected fMRI data in younger and older participants during resting state, a selective attention (SA) task and an n-back working memory task with varying levels of difficulty. Spatial independent component (IC) analysis was used to identify functional networks over all participants and all conditions. Dual regression was used to obtain participant and task specific time-courses per IC. Subsequently, functional connectivity was computed between all ICs in each of the tasks. Based on these functional connectivity matrices, a scaled version of the eigenvector centrality (SEC) was used to measure the total influence of each IC in the complete graph of ICs. The results demonstrated that elderly remain able to adapt FNC to task demands. However, there was an age-related shift in the impetus for FNC change. Older participants showed the maximal change in SEC patterns between resting state and the SA task. Young participants, showed the largest shift in SEC patterns between the less demanding SA task and the more demanding 2-back task. Our results suggest that increased FNC changes from resting state to low demanding tasks in elderly reflect recruitment of additional resources, compared with young adults. The lack of change between the low and high demanding tasks suggests that elderly reach a resource ceiling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.